西宁地区毒性弥漫性甲状腺肿甲状腺功能亢进症流行病学调查及影响因素  

Influencing factors and epidemiological survey of diffuse toxic goiter with hyperthyroidism in Xining

作　　者：李永桂 朱沁芳[1] 李小鸾[1] 张玲明 LI Yonggui;ZHU Qinfang;LI Xiaoluan;ZHANG Lingming(Department of Endocrinology,Qinghai Provincial People′s Hospital,Xining,Qinghai 810007,China)

机构地区：[1]青海省人民医院内分泌科,青海西宁810007

出　　处：《公共卫生与预防医学》2024年第5期138-141,共4页Journal of Public Health and Preventive Medicine

基　　金：青海省科技计划项目(2020-ZJ-930)。

摘　　要：目的调查西宁地区毒性弥漫性甲状腺肿甲状腺功能亢进症(简称甲亢)流行病学现状,并分析其影响因素。方法采用随机整群抽样法收集于2020年1月至2023年1月西宁地区三甲医院住院的弥漫性甲状腺肿甲亢患者为实验组,同期选择500例健康人群作为对照组,对比患者的一般资料采用多因素logistic回归分析弥漫性甲状腺肿甲亢发病的影响因素。结果患者以41~50岁女性人群居多。实验组血清TSH水平低于对照组,FT3、FT4水平高于对照组(P<0.05)。两组在突眼、甲状腺重量方面差异有统计学意义(P<0.05)。经多因素Logistic回归分析显示,突眼、甲状腺重量≥30g、TSH、FT3、FT4为实验组的独立危险因素(P<0.05)。结论西宁地区弥漫性甲状腺肿甲亢性别、年龄、突眼、甲状腺重量及甲状腺相关激素水平为其发病影响因素,应监测其甲状腺功能以对疾病进行早期防治。Objective To investigate the epidemiological status of toxic diffuse goiter hyperthyroidism(abbreviated as hyperthyroidism)in Xining area and analyze its influencing factors.Methods Patients with toxic diffuse goiter and hyperthyroidism who were hospitalized in ClassⅲGrade A hospitals in Xining from January 2020 to January 2023 were collected as the experimental group by random cluster sampling method.During the same period,500 healthy people in each hospital were selected as the control group.The general data of the patients were collected and the levels of thyroid function indexes of the two groups were detected.Multivariate logistic regression was used to analyze the influencing factors of diffuse goiter with hyperthyroidism.Results A total of 718 questionnaires were collected in this study,and 705 questionnaires were collected after excluding invalid questionnaires.There were 234 males and 471 females in 705 patients with diffuse goiter and hyperthyroidism.The most common age was 41-50 years,followed by 51-60 years and 31-40 years.The serum TSH level of the experimental group was lower than that of the control group,and the levels of FT3 and FT4 were higher than those of the control group(P<0.05).There was no significant difference in family history,thyroid texture and thyroid imaging between the two groups(P>0.05).There were significant differences in exophthalmos and thyroid weight between the two groups(P<0.05).Multivariate logistic regression analysis showed that exophthalmos,thyroid weight≥30g,TSH,FT3 and FT4 were independent risk factors for the experimental group(P<0.05).Conclusion Gender,age,exophthalmos,thyroid weight and thyroid related hormone levels are the influencing factors of diffuse goiter and hyperthyroidism in Xining area.Thyroid function should be monitored for early prevention and treatment of the disease.

关 键 词：毒性弥漫性甲状腺肿 甲状腺功能亢进症 流行病学 影响因素 

分 类 号：R181[医药卫生—流行病学]