Advances in cytokine-mediated mechanisms for cardiac regeneration and repair post-myocardial infarction:a comprehensive review  

作　　者：Zi-Heng Zhang Yang Yang 

机构地区：[1]College of Life Sciences,Xinjiang University,Urumqi 830046,China [2]Clinical Systems Biology Laboratories,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

出　　处：《Pharmacology Discovery》2024年第3期30-35,共6页

基　　金：supported by the Henan Medical Science and Technology Joint Building Program(No.LHGJ20230283);the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079).

摘　　要：Cardiovascular disease(CVD)has become the leading cause of death globally,imposing significant health and economic burdens.Among these,myocardial infarction(MI)is a predominant cause of mortality.Several animal studies have shown that cytokines participate in cardiac regeneration and repair by modulating cellular proliferation,differentiation,and apoptosis post-MI.Here,we explored the crucial role of cytokines in cardiac regeneration and repair processes in experimental animal models,detailing how cytokines modulate cellular mechanisms involved in repairing cardiac tissue post myocardial infarction(MI).Specifically,it highlights the activation of cardiac stem cells and progenitors,the regulation of inflammatory responses to prevent excessive damage,and the involvement in matrix remodeling to ensure functional integrity of the heart.This comprehensive examination underscores the therapeutic potential of enhancing cytokine secretion to mitigate adverse effects and promote recovery following MI,offering insights into possible interventions that could improve patient outcomes in clinical settings.

关 键 词：CYTOKINES myocardial infarction experimental animal model promotion of cytokine release 

分 类 号：R54[医药卫生—心血管疾病]