富血小板血浆联合周围神经松解术治疗糖尿病足溃疡创面的临床效果观察  

Clinical observation of platelet-rich plasma combined with peripheral nerve release in the treatment of diabetic foot ulcer wounds

作　　者：韦礼永 韦仁杰[1] 黄大波[1] Wei Liyong;Wei Renjie;Huang Dabo(Department of Traumatic and Hand Surgery,Hechi People's Hospital of Guangxi,Hechi 547000,China)

机构地区：[1]广西河池市人民医院创伤手外科,河池547000

出　　处：《中华手外科杂志》2024年第4期372-376,共5页Chinese Journal of Hand Surgery

基　　金：广西壮族自治区卫健委科研课题(20211018)。

摘　　要：目的探讨应用富血小板血浆(platelet-rich plasma,PRP)局部注射联合周围神经松解术治疗糖尿病足溃疡创面的临床效果.方法对我院自2020年1月至2023年6月收治的162例糖尿病足患者病例资料进行回顾性研究,其中对照组(A组)43例:控制感染,常规处理创面,方法包括创面外科清创、红蓝光治疗等;神经松解组(B组)38例:创面常规处理方法同对照组,并在此基础上行周围神经松解术减压治疗;PRP组(C组)46例:创面常规处理方法同对照组,创面定期使用PRP局部注射;联合治疗组(D组)35例:创面常规处理方法同对照组,并在此基础上行周围神经松解术减压治疗,同时创面定期使用PRP局部注射.比较四组创面愈合率、愈合疗效、患肢疼痛程度等.结果治疗3周后D组创面愈合率为(68.39±5.64)%,高于A组(52.21±4.83)%、B组(57.94±5.12)%、C组(62.91±5.38)%,差异有统计学意义(P<0.05).治疗6周后D组创面治疗有效率为91.43%,高于A组(74.42%)、B组(81.58%)、C组(84.78%),D组与A组比较差异有统计学意义(P<0.05),与B组、C组比较差异无统计学意义(P>0.05).D组疼痛视觉模拟评分(visual analogue scale,VAS)为(1.34±0.37)分,低于A组(2.48±0.55)分、B组(1.74±0.46)分、C组(1.85±0.49)分,差异有统计学意义(P<0.05).结论应用PRP局部注射联合周围神经松解术治疗能有效控制糖尿病足溃疡创面感染,有效缓解患肢疼痛,加速糖尿病足创面的愈合速度,缩短创面愈合时间,提高创面愈合率.Objective To explore the clinical efficacy of local injection of platelet-rich plasma(PRP)combined with peripheral nerve release in the treatment of diabetic foot ulcer wounds.Methods A retrospective study was carried out on 162 patients with diabetic foot who were admitted to our hospital from January 2020 to June 2023.Among them,43 cases in the control group(Group A):control of infection,routine treatment of wounds,including surgical debridement of wounds,red and blue light treatment,etc;38 cases in the nerve release group(Group B):the conventional wound treatment method was the same as the control group,and peripheral nerve release surgery was performed on this basis for decompression treatment;46 cases in the PRP group(Group C):the conventional wound treatment method was the same as the control group,and the wound was regularly injected with PRP locally;35 cases in the combination treatment group(Group D):the conventional wound treatment method was the same as the control group,and peripheral nerve decompression treatment was performed on this basis.At the same time,PRP local injection was regularly used on the wound.The wound healing rate,healing efficacy,and degree of limb pain among four groups were compared.Results After 3 weeks of treatment,the wound healing rate of Group D was(68.39±5.64)%,which was higher than that of Group A(52.21±4.83)%,Group B(57.94±5.12)%,and Group C(62.91±5.38)%,and the difference was statistically significant(P<0.05).After 6 weeks of treatment,the effective rate of wound treatment in Group D was 91.43%,which was higher than Group A(74.42%),Group B(81.58%),and Group C(84.78%).The difference between Group D and Group A was statistically significant(P<0.05),but there was no statistically significant difference between Group D and Group B and Group C(P>0.05).The visual analogue scale(VAS)for pain in Group D was(1.34±0.37)points,which was lower than Group A's(2.48±0.55)points,Group B's(1.74±0.46)points,and Group C's(1.85±0.49)points,and the difference was statistically signifi

关 键 词：糖尿病足 治疗结果 富血小板血浆 神经松解 

分 类 号：R587.2[医药卫生—内分泌]