2011—2022年郑州市5岁以下腹泻儿童肠道腺病毒流行特征分析  

Epidemiological characteristics of enteric adenovirus in children under 5 years old with diarrhea in Zhengzhou,2011-2022

作　　者：段晶晶[1] 姚卓 郑云鹏[3] 徐兰英[1] 李国伟[1] 胡乃月 申晓靖[4] 赵嘉咏[4] Duan Jingjing;Yao Zhuo;Zheng Yunpeng;Xu Lanying;Li Guowei;Hu Naiyue;Shen Xiaojing;Zhao Jiayong(Institute for Infectious Disease Prevention and Control,Zhengzhou Center for Disease Control and Prevention,Zhengzhou 450007,China;Gastroenterology Department,Zhengzhou Children's Hospital,Zhengzhou 450053,China;Department for Dermatology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Institute for Infectious Disease Prevention and Control,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China)

机构地区：[1]郑州市疾病预防控制中心传染病预防控制所,450007 [2]郑州儿童医院消化内科,450053 [3]郑州大学第一附属医院皮肤科,450052 [4]河南省疾病预防控制中心传染病预防控制所,郑州450016

出　　处：《国际病毒学杂志》2024年第4期327-330,共4页International Journal of Virology

基　　金：河南省医学科技攻关计划项目(LHGJ20230772)。

摘　　要：目的了解郑州市5岁以下腹泻儿童肠道腺病毒的感染状况和流行特征,为相关疾病的防控提供参考。方法采集2011—2022年郑州市哨点医院5岁以下腹泻住院儿童粪便样本2241份,冷冻状态下送至实验室,用PCR方法检测肠道腺病毒,定性资料比较采用χ2检验。结果共检出肠道腺病毒阳性样本183份,总阳性率为8.17%。全年各月均可检出,高发季节为冬春季,1岁以内儿童肠道腺病毒阳性率较低,其余年龄组多在10%以上。肠道腺病毒阳性率差异与发热温度及是否呕吐有统计学意义(P<0.05),与腹泻次数无统计学意义(P>0.05)。结论近年来郑州市5岁以下腹泻儿童的肠道腺病毒阳性率整体呈上升趋势,应进一步加强儿童肠道腺病毒感染性腹泻的监测与防控力度,防止暴发疫情的发生。ObjectiveTo investigate the infection status and epidemiological features of enteric adenovirus in children under the age of 5 years old in Zhengzhou,so as to provide evidences for the prevention and control of enteric adenovirus infection.MethodsA total of 2241 stool samples were collected from hospitalized children under the age of 5 years with diarrhea in the sentinel hospitals between 2011 and 2022.All samples were sent to the laboratory in frozen and were used for detection of intestinal adenovirus by PCR.Chi-square test was used for the comparison of qualitative data.ResultsA total of 183 enteric adenovirus positive samples were detected from 2011 to 2022 and the overall positive rate was 8.17%.There were positive detections every month of the years and the peak seasons were winters and springs.The positive rate of enteric adenovirus in children under one year old was low and the rate was over 10%in other age groups.The differences in positive rates of enteric adenovirus,body temperature in fever and occurrence of vomiting were statistically significant(P<0.05),while the difference in frequency of diarrhea was not statistically significant(P>0.05).ConclusionsThe positive rate of enteric adenovirus in children under 5 years old with diarrhea showed a trend of increasing in Zhengzhou.The surveillance as well as prevention and control interventions of diarrhea in children caused by enteric adenovirus should be enhanced in further to prevent outbreaks.

关 键 词：儿童 腹泻 流行特征 肠道腺病毒 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]