A mechanically stable self-pumping organohydrogel dressing with aligned microchannels for accelerated diabetic wound healing  

一种具有定向微通道的机械稳定的自泵油水凝胶敷料用于加速糖尿病伤口愈合

作　　者：Wuyi Xiao Xizi Wan Yikai Zhang Jinze Lan Lianxin Shi Shutao Wang 肖五一;万茜子;张益锴;兰晋泽;时连鑫;王树涛(CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China;University of Chinese Academy of Sciences,Beijing,100049,China;Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou,215123,China)

机构地区：[1]CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou,215123,China

出　　处：《Science China Materials》2024年第9期2995-3002,共8页中国科学（材料科学）（英文版）

基　　金：supported by the National Natural Science Foundation of China(22035008,21972155,22002177,and 22205244);Youth Innovation Promotion Association,Chinese Academy of Sciences(CAS)(2022027);CAS-Croucher Funding Scheme for Joint Laboratories;China Postdoctoral Science Foundation(2022M713225)。

摘　　要：Self-pumping dressings(SPDs)have been developed as a new type of effective material for the drainage of excessive wound exudates based on the structure of asymmetric wettability.However,current SPDs are easy to lose their asymmetric wettability due to the weak interfacial mechanical stability between the hydrophobic and hydrophilic layers.Herein,we report an integrated self-pumping organohydrogel dressing with aligned microchannels(SPD-AM),prepared by an ice-templating-assisted wetting-enabled-transfer(WET)polymerization strategy,that can accelerate the healing process of diabetic wounds.The WET polymerization strategy enables strong interfacial mechanical stability between the hydrophobic organogel and hydrophilic hydrogel layers.The aligned microchannels greatly improve the draining capability of SPDs.Taking a diabetic rat model as an example,the SPD-AM can significantly reduce the bacterial colonization with low inflammatory responses,enhance dermal remodeling by about 47.31%,and shorten wound closure time by about 1/5 compared with other dressings,ultimately accelerating diabetic wound healing.This study is valuable for developing next-generation SPDs with stable mechanical performance for clinical applications.基于非对称浸润性结构的自泵敷料(SPDs)已发展成为一种用于伤口过量渗液引流的新型有效材料,然而,由于亲、疏水层之间的界面力学稳定性较弱,目前的SPDs容易失去其不对称浸润性.为此,我们通过冰模板辅助浸润诱导转移(WET)聚合策略,制备了一种一体化的、具有定向微通道的自泵油水凝胶敷料(SPD-AM),可以加速糖尿病伤口的愈合过程.WET策略使疏水油凝胶层和亲水水凝胶层之间具有强界面力学稳定性,定向排列的微通道大大提高了SPD的导水能力.以糖尿病大鼠模型为例,相比其他敷料,SPD-AM可显著减少细菌定植,降低炎症反应,促进真皮重塑约47.31%,缩短创面愈合时间约1/5,并最终加速糖尿病创面愈合.本研究对开发下一代面向临床应用的具有稳定力学性能的自泵敷料具有重要价值.

关 键 词：SPDs mechanically stable interfaces WET strategy ice-templating organohydrogel diabetic wounds 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]