Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections Author links open overlay panel  

作　　者：Ying Li Nan Tang Lingling Zhao Xingfu Bao Yuzhuo Wang Zhanxin Wang Min Hu 

机构地区：[1]Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School and Hospital of Stomatology,Jilin University,Changchun,China [2]Beijing Advanced Innovation Center for Soft Matter Science and Engineering,College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,China

出　　处：《Particuology》2024年第8期190-201,共12页颗粒学报（英文版）

基　　金：funded by the National Natural Science Foundation of China(grant Nos.82170994 and 22178140);the Jilin Province Department of Finance(grant Nos.JCSZ2020304-11,JCSZ2023481-4,and JCSZ2023481-6).All schemes were prepared by authors with BioRender.com。

摘　　要：Oral infectious diseases caused by a variety of pathogenic bacteria seriously affect the quality of life.However,these diseases remain a clinical challenge because of the lack of simple,safe,and universal prophylactics.To address these limitations,we synthesize CuO_(x)nanodots(CuO_(x)NDs)with excellent Fenton-like reaction activity and utilize them in the treatment of oral bacterial infections.Different from other complicated approaches,CuO_(x)NDs are rationally prepared using a facile one-pot aqueous synthesis.In the presence of H_(2)O_(2),these well-developed CuO_(x)NDs can efficiently catalyze the generation of hydroxyl radicals(·OH)around oral pathogens,leading to the death of various bacteria.Meanwhile,results of biosafety indicate the high biocompatibility and extremely low toxicity of these CuO_(x)NDs.After understanding the admirable in vitro antibacterial effect of CuO_(x)NDs in the presence of H_(2)O_(2),we further explore their in vivo antibacterial performance on several classical animal models including oral mucosal wound model,intragingival bacteria-infected model,and the periodontal infection model.As expected,these CuO_(x)NDs with wide-spectrum antibacterial activity can serve as high-performance antibacterial reagents for the treatment of various oral bacterial infections with the help of H_(2)O_(2).In brief,current nanoplatform can act as efficient antibiotics against oral pathogens with broadening the biomedical applications of copper-based nanomaterials.

关 键 词：Antibacterial treatment Oral diseases Fenton-likecatalytic reaction Reactive oxygen species 

分 类 号：R318[医药卫生—生物医学工程] R78[医药卫生—基础医学] TB383[一般工业技术—材料科学与工程]