吲哚美辛联合奥曲肽对ERCP术后胰腺炎及高淀粉酶血症的预防效果观察  

Observation on the preventive effect of indomethacin combined with octreotide on pancreatitis and hyperamylasemia after ERCP

作　　者：李强 Li Qiang(People's Hospital of Pingxiang City,Jiangxi337000)

机构地区：[1]江西省萍乡市人民医院,江西337000

出　　处：《天津药学》2024年第4期53-56,共4页Tianjin Pharmacy

摘　　要：目的:探讨吲哚美辛联合奥曲肽对经内镜逆行胰胆管造影(ERCP)术后胰腺炎及高淀粉酶血症的预防效果。方法:以随机数字表法将2020年1月—2022年12月于本院行ERCP治疗的80例患者分为两组,各40例。对照组术前1 h便开始静脉滴注奥曲肽,持续1 d,1 mg/(kg·h);观察组在对照组基础上于术后0.5 h予以吲哚美辛,取栓剂1枚塞于肛门。两组术后均予以补液、抗感染处理。比较两组临床相关指标、术后疼痛、并发症发生情况,另外观察两组用药安全性。结果:两组术前血清淀粉酶、C-反应蛋白(CRP)水平和疼痛评分比较无统计学差异(P>0.05);观察组术后血清淀粉酶、CRP水平和疼痛评分低于对照组,有统计学差异(P<0.05)。观察组胰腺炎和术后不同时点高淀粉酶血症发生率均低于对照组,有统计学差异(P<0.05)。两组均未发生明显不良反应。结论:吲哚美辛联合奥曲肽是一种行之有效的预防手段,可降低术后血清淀粉酶和CRP水平,缓解疼痛,降低胰腺炎及高淀粉酶血症发生风险。Objective:To investigate the preventive effect of indomethacin combined with octreotide on pancreatitis and hyperamylasemia after endoscopic retrograde cholangiopancreatography(ERCP).Methods:Eighty patients treated with ERCP in our hospital between January 2020 and December 2022 were randomly divided into two groups,with 40 patients in each group.The control group began intravenous infusion of octreotide 1 h before the operation for 1 d at 1 mg/(kg·h).The observation group was given indomethacin 0.5 h after operation on the basis of the control group,and one suppository was taken and stuffed in the anus.Both groups were treated with rehydration and anti-infection after surgery.The clinical indices,postoperative pain,and complications of the two groups were compared,and the drug safety of the two groups was observed.Results:There were no significant differences in serum amylase,C-reactive protein(CRP),or pain scores between the two groups(P>0.05).The serum amylase and CRP levels and pain scores in the observation group were lower than those in the control group(P<0.05).The incidence of pancreatitis and hyperamylasemia in the observation group was lower than that in the control group(P<0.05).No obvious adverse reactions were observed in either group.Conclusion:Indomethacin combined with octreotide is an effective preventive measure that can reduce the levels of serum amylase and CRP after surgery,relieve pain,and reduce the risk of pancreatitis and hyperamylasaemia.

关 键 词：经内镜逆行胰胆管造影 吲哚美辛 奥曲肽 术后胰腺炎 高淀粉酶血症 

分 类 号：R657.5[医药卫生—外科学]