米诺环素与头孢西丁钠对急性盆腔炎患者炎性包块直径及盆腔积液深度的影响  

Effect of Minocycline and Cefoxitin Sodium on Diameter of Inflammatory Mass and Depth of Pelvic Effusion in Patients with Acute Pelvic Inflammatory Disease

作　　者：周璇 ZHOU Xuan(Department of Obstetrics and Gynecology,Shiyan Maojian District People's Hospital,Shiyan 442000,China)

机构地区：[1]十堰市茅箭区人民医院妇产科,湖北十堰442000

出　　处：《中国药物经济学》2024年第8期62-65,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨米诺环素、头孢西丁对急性盆腔炎患者炎性包块直径、盆腔积液深度的影响。方法选取2022年8月至2023年8月十堰市茅箭区人民医院收治的急性盆腔炎患者87例作为研究对象,按照随机数字表法分为观察组(n=44)和对照组(n=43)。对照组给予头孢西丁钠治疗,观察组在对照组基础上采用米诺环素治疗,比较两组患者盆腔积液深度、炎性包块直径、炎症因子水平、治疗效果。结果治疗前观察组盆腔积液深度、炎性包块直径与对照组比较差异无统计学意义(P>0.05);治疗后观察组盆腔积液深度、炎性包块直径低于对照组(P<0.05);治疗前两组C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比较差异无统计学意义(P>0.05);治疗后观察组CRP、IL-6、TNF-α水平低于对照组(P<0.05);观察组治疗有效率高于对照组(P<0.05)。结论对急性盆腔炎患者给予米诺环素、头孢西丁钠治疗,疗效显著,可减轻炎症反应,降低盆腔积液深度及缩小炎性包块直径。Objective To explore the effects of minocycline and cefoxitin on the diameter of inflammatory mass and the depth of pelvic effusion in patients with acute pelvic inflammatory disease.Methods Eighty-seven patients with acute pelvic inflammatory disease treated in Maojian District People's Hospital of Shiyan City from August 2022 to August 2023 were selected as the study objects,and were divided into observation group(n=44)and control group(n=43)according to random number table method.The control group was treated with cefoxitin sodium,and the observation group was treated with minocycline on the basis of the control group.The depth of pelvic effusion,the diameter of inflammatory mass,the level of inflammatory factors and the therapeutic effect of the two groups were compared.Results Before treatment,there was no significant difference in the depth of pelvic effusion and diameter of inflammatory mass between the observation group and the control group(P>0.05).After treatment,the depth of pelvic effusion and diameter of inflammatory mass in observation group were lower than those in control group(P<0.05).There was no significant difference in C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels between the two groups before treatment(P>0.05).After treatment,the levels of CRP,IL-6 and TNF-αin observation group were lower than those in control group(P<0.05).The effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion Treatment with minocycline and cefoxitin sodium in patients with acute pelvic inflammatory disease is effective,which can reduce inflammatory response,reduce the depth of pelvic effusion and reduce the diameter of inflammatory mass.

关 键 词：米诺环素 头孢西丁钠 急性盆腔炎 炎性包块直径 

分 类 号：R711.3[医药卫生—妇产科学] R978.1[医药卫生—临床医学]