中国两广地区新献血浆者的血尿酸和血脂水平调查分析  

Levels of Serum Uric Acid and Lipid in First-time Plasma Donors in Guangdong and Guangxi

作　　者：黄耀敬 陈正康 陆爱红 陆柏桦 朱怡宽 黄俊立 叶兰 周玉飞 HUANG Yaojing;CHEN Zhengkang;LU Aihong;LU Baiye;ZHU Yikuan;HUANG Junli;YE Lan;ZHOU Yufei(Research and Development Department,Bama RAAS Apheresis Plasma Co.,Ltd.,Bama,Guangxi 547500)

机构地区：[1]巴马莱士单采血浆站,广西巴马547500 [2]遂溪双林单采血浆有限公司,广东遂溪524300 [3]廉江双林单采血浆有限公司,广东廉江524421 [4]平果光明单采血浆有限公司,广西平果531400

出　　处：《临床输血与检验》2024年第4期521-530,共10页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的调查中国两广地区法定单采血浆区域新献血浆者的血尿酸和血脂水平状况,并分析其影响因素。方法通过完全随机抽样的方式随机选取2021年4月—2022年8月来自广西内陆地区(巴马和平果)和广东沿海地区(遂溪和廉江)4家单采血浆公司的合计11485名新献血浆者,检测其血尿酸、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇和甘油三酯水平,并对检测结果进行统计分析。结果11485名新献血浆者中血尿酸异常者占比为22%,血脂异常率为57.6%;其中UA、LDL-C、TC及TG水平与新献血浆者年龄显著相关(UA:r_(全部)=‒0.291,r_(男性)=‒0.138,r_(女性)=‒0.170;r_(LDL-C)=0.300,r_(TC)=0.340,r_(TG)=0.234;P<0.001);UA、HDL-C、LDL-C、TC及TG水平与新献血浆者BMI显著相关(UA:r_(全部)=0.201,r_(男性)=0.243,r_(女性)=0.241;r_(HDL-C)=-0.273,r_(LDL-C)=0.316,r_(TC)=0.275,r_(TG)=0.335;P<0.001);不同献浆区域间的新献浆者血尿酸(UA)和血(HDL-C,LDL-C,TC,TG)水平均存在显著差异(P<0.001);不同血型新献血浆者间的HDL-C、LDL-C和TC水平存在显著差异(P<0.001);新献血浆者中男性的UA和TG水平显著高于女性(UA:366μmol/L v s 262μmol/L,TG:1.4 mmol/L vs 1.4 mmol/L;P<0.001),女性新献血浆者的HDL-C和TC水平显著高于男性(HDL-C:1.1 mmol/L vs 0.9 mmol/L,TC:3.7 mmol/L vs 3.6 mmol/L;P<0.001);汉族和少数民族新献血浆者间的UA、HDL-C和TC水平存在显著差异(P<0.001);不同地区、性别、血型和民族的新献血浆者间血尿酸和血脂异常率存在显著差异(P<0.001);新献血浆者的浆站区域、血脂异常情况、性别、年龄、体重及身高是其血尿酸异常的独立风险因素(P<0.001);新献血浆者的浆站区域、血尿酸异常、性别、血型、年龄、体重及身高是其血脂异常的独立风险因素(P<0.001);新献血浆者的浆站区域、性别、体重及身高是其血尿酸和血脂异常的独立风险因素(P<0.001)。结论中国两广地区新献血浆者Objective To investigate the levels of serum uric acid(SUA)and lipids in first-time donors from Guangdong and Guangxi provinces and its risk factors.Methods A total of 11485 first-time donors in Guangxi(Bama and Pingguo)and coastal areas in Guangdong(Suixi and Lianjiang)between April 2021 and August 2022 by completely random sampling were randomly selected.The levels of SUA,high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),total cholesterol(TC)and triglyceride(TG)were analyzed.Results Among the 11485 first-time donors,the proportion of abnormal SUA was 22%and dyslipidemia rate was 57.6%.The levels of UA,LDL-C,TC and TG were significantly correlated with age(UA:r_(all)=‒0.291,r_(male)=‒0.138,r_(female)=‒0.170;r_(LDL-C)=0.300,r_(TC)=0.340,r_(TG)=0.234;P<0.001).The levels of SUA,HDL-C,LDL-C,TC and TG were significantly correlated with their BIM(UA:r_(all)=0.201,r_(male)=0.243,r_(female)=0.241;r_(HDL-C)=‒0.273,r_(LDL-C)=0.316,r_(TC)=0.275,r_(TG)=0.335;P<0.001).There were significant differences in SUA and lipids(HDL-C,LDL-C,TC,TG)among firsttime donors in different plasma station(P<0.001).There were significant differences in the levels of HDL-C,LDL-C and TC among different blood types(P<0.001).The levels of SUA and TG in males were significantly higher than those in females(UA:366μmol/L vs 262μmol/L,TG:1.4 mmol/L vs 1.4 mmol/L,P<0.001).The levels of HDL-C and TC in females were significantly higher than those in males(HDL-C:1.1 mmol/L vs 0.9 mmol/L,TC:3.7 mmol/L vs 3.6 mmol/L,P<0.001).There were significant differences in SUA,HDL-C and TC levels between Han nationality and ethnic minorities(P<0.001).The rates of abnormal SUA and dyslipidemia among different regions,genders,blood types and nationalities(P<0.001).The plasma station,dyslipidemia,sex,age,weight and height of donors were independent risk factors(P<0.001).The plasma station,abnormal SUA,sex,blood type,age,weight and height were independent risk factors for dyslipidemia(P<0.001).The plasma station,sex,weight and height were independe

关 键 词：新献血浆者 血尿酸 血脂 血尿酸异常 血脂异常 

分 类 号：R457.14[医药卫生—治疗学] R446.112[医药卫生—临床医学]