2018-2022年我国18家省级血液中心献血者HCV检测结果分析  

HCV Detection among Blood Donors from 18 Provincial Blood Centers in China from 2018 to 2022

作　　者：李雨薇 黄霞[2] 周源 刘颖 王林[5] 邹彬彬[6] 刘胡敏[7] 马海莉[8] 许婷婷[9] 唐飞[10] 曹铭静 侯玲华 李玉军[13] 胡文佳[14] 冯惟萍[15] 刘妍妍 段勇[17] 温涛[18] 李明霞[19] 邱艳[20] LI Yuwei;HUANG Xia;ZHOU Yuan;LIU Ying;WANG Lin;ZOU Binbin;LIU Humin;MA Haili;XU Tingting;TANG Fei;CAO Mingjing;HOU Linghua;LI Yujun;HU Wenjia;FENG Weiping;LIU Yanyan;DUAN Yong;WEN Tao;LI Mingxia;QIU Yan(Baoji Blood Center,Shaanxi,721000;不详)

机构地区：[1]宝鸡市中心血站,陕西宝鸡 [2]重庆市血液中心,重庆 [3]太原市血液中心,山西太原 [4]黑龙江省血液中心,黑龙江哈尔滨 [5]海南省血液中心,海南海口 [6]长沙血液中心,湖南长沙 [7]成都市血液中心,四川成都 [8]云南昆明血液中心,云南昆明 [9]武汉血液中心,湖北武汉 [10]贵州省血液中心,贵州贵阳 [11]山东省血液中心,山东济南 [12]河北省血液中心,河北石家庄 [13]宁夏回族自治区血液中心,宁夏银川 [14]江苏省血液中心,江苏南京 [15]甘肃省红十字血液中心,甘肃兰州 [16]天津市血液中心,天津 [17]陕西省血液中心,陕西西安 [18]河南省红十字血液中心,河南郑州 [19]乌鲁木齐市血液中心,新疆乌鲁木齐 [20]北京市红十字血液中心,北京

出　　处：《临床输血与检验》2024年第5期638-645,共8页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：中国输血协会圣湘输血医学发展基金资助项目(No.CSBT-SX-2023-1)资助。

摘　　要：目的分析我国省级血液中心服务区域献血人群丙型肝炎病毒(hepatitis C virus,HCV)检测数据。方法对我国东中西部不同地区的18家省级血液中心,2018—2022年初次献血和重复献血者抗-HCV和HCV RNA检测数据收集整理,分析献血者中抗-HCV ELISA和抗-HCV ELISA阴性中HCV RNA检测不合格率与年度、血液中心以及初次献血和重复献血者之间的关系。结果2018年—2022年HCV总不合格率从24.61/万逐年减少至15.17/万(χ^(2)=717.71,P<0.01),西部地区为25.72/万最高,东部11.96/万最低(χ^(2)=2382.54,P<0.01);初次献血者抗-HCV ELISA不合格率(30.50/万)比重复献血者(7.42/万)高(χ^(2)=9694.63,P<0.01);各血液中心抗-HCV ELISA阴性中HCV-RNA单独不合格率范围为0~7.54/万。结论我国18家血液中心服务区域献血者的HCV检测不合格率呈逐年降低趋势;HCV检测不合格率存在明显的地域分布差异;与初次献血者相比,重复献血者为HCV检测不合格低危人群;HCV-RNA检测在血液安全方面发挥重要作用。Objective The data of hepatitis C virus(HCV)among blood donors in the service areas of provincial blood centers were analyzed.Methods Anti-HCV and HCV RNA data from 2018 to 2022 from first-time and repeat donors at 18 provincial blood HCV ELISA and anti-HCV ELISA negative RNA was analyzed.These was related to the year,blood center,and first-time and repeat donors.Results Between 2018 and 2022,the total unqualified rate of HCV decreased from 26.61/10000 to 15.17/10000(χ^(2)=717.71,P<0.01).The highest rate was 25.72/10000 in western China and the lowest rate was 11.96/10000 in eastern China.The unqualified rate of anti-HCV ELISA in first-time blood donors(30.50/10000)was higher than that in repeat blood donors(7.42/10000).The unqualified rate of anti-HCV ELISA negative HCV-RNA in each blood center ranged from 0 to 7.54/10000.Conclusion The unqualified rate of HCV among blood donors in 18 centers decreased year by year.There are significant regional characteristics in the unqualified rate of HCV detection.Compared with the first-time blood donors,repeat donors were a lower-risk group.HCV RNA testing played an important role in blood safety.

关 键 词：献血者 丙型肝炎病毒 不合格率 抗-HCV ELISA HCV RNA检测 

分 类 号：R457[医药卫生—治疗学]