基于“肾脑相济”理论与线粒体稳态相关性探讨补肾方药治疗阿尔茨海默病的机制  

Discussion on the mechanism of kidney-tonifying prescription for Alzheimer′s disease based on the correlation between the theory of“interaction between kidney and brain”and mitochondrial homeostasis

作　　者：朱超 张正 朱友松 韩诚 赵琼 秦亚莉 Zhu Chao;Zhang Zheng;Zhu Yousong;Han Cheng;Zhao Qiong;Qin Yali(National International Joint Research Center for Molecular Traditional Chinese Medicine,Shanxi University of Chinese Medicine,Jinzhong Shanxi 030619;Shanxi Key Laboratory of Traditional Chinese Medicine for Brain Diseases,Jinzhong Shanxi 030619;Shanxi University of Chinese Medicine,Jinzhong Shanxi 030619)

机构地区：[1]山西中医药大学分子中医药学国家级国际联合研究中心,山西晋中030619 [2]中医脑病学山西省重点实验室,山西晋中030619 [3]山西中医药大学,山西晋中030619

出　　处：《山西中医药大学学报》2024年第7期806-810,共5页Journal of Shanxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81874420,82004236,81703959);山西省基础研究计划项目(202203021211222);山西省中医药管理局科研计划项目(2022ZYYC280);山西省研究生科研创新项目(2023KY681);山西中医药大学研究生创新项目(2023CX032)。

摘　　要：阿尔茨海默病(AD)是一种与年龄密切相关的神经退行性疾病,机体进程性的衰老是导致AD发生的因素之一,脑内能量代谢异常、神经元损伤或凋亡则是其主要病理特征。现代研究表明,上述三者的发生与线粒体稳态失衡存在着紧密的联系。中医学认为AD责之于“肾脑失济”,补肾填精是根本治疗之法。基于“肾脑相济”理论及现代研究,探究“肾脑相济”理论与线粒体稳态的相关性,发现补肾方药可以通过纠正线粒体稳态失衡来延缓机体衰老,改善AD患者脑内能量代谢异常、神经元损伤或凋亡。因此在AD中,肾精与线粒体稳态具有相关性,补肾方药治疗AD的科学内涵是改善线粒体稳态失衡。Alzheimer′s disease(AD)is a neurodegenerative disorder closely associated with aging,where progressive aging is one factor leading to AD,while abnormal energy metabolism in the brain,neuronal damage,or apoptosis are its main pathological features.Modern research indicates that these three phenomena are closely related to mitochondrial homeostasis imbalance.According to traditional Chinese medicine,AD is attributed to“disharmony between kidney and brain,”and replenishing kidney essence is considered the fundamental treatment approach.Based on the theory of“interaction between kidney and brain”and modern studies,this paper explores the correlation between the theory of“interaction between kidney and brain”and mitochondrial homeostasis.It finds that kidney-tonifying prescription can correct mitochondrial homeostasis imbalance,thereby delaying organismal aging and improving abnormal energy metabolism and neuronal damage or apoptosis in AD patients.Therefore,in AD,kidney essence and mitochondrial homeostasis are correlated,and the scientific basis of treating AD with kidney-tonifying prescription lies in improving mitochondrial homeostasis imbalance.

关 键 词：阿尔茨海默病 “肾脑相济” 线粒体稳态 精髓 肾精 

分 类 号：R28[医药卫生—中药学]