广州出生队列研究的理念与实践  

Principles and practice of the Born in Guangzhou Cohort Study

作　　者：邱琇 韦冬梅 林珊珊 夏慧敏 周文浩 QIU Xiu;WEI Dongmei;LIN Shanshan;XIA Huimin;ZHOU Wenhao(Division of Birth Cohort Study,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,510623,China;Department of Women's Health,Guangdong Provincial Key Clinical Specialty of Woman and Child Health,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,510623,China;Department of Pediatric Surgery,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,510623,China;Division of Neonatology,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,510623,China)

机构地区：[1]广州医科大学附属妇女儿童医疗中心出生队列研究室,广东广州510623 [2]广州医科大学附属妇女儿童医疗中心妇女保健部,广东省高水平临床重点专科(妇幼保健),广东广州510623 [3]广州医科大学附属妇女儿童医疗中心新生儿外科,广东广州510623 [4]广州医科大学附属妇女儿童医疗中心新生儿科,广东广州510623

出　　处：《临床儿科杂志》2024年第9期747-752,共6页Journal of Clinical Pediatrics

基　　金：国家自然科学基金面上项目(No.82173525)。

摘　　要：出生队列是探讨生命早期因素对子代生命历程健康的重要研究手段和资源,但目前国内缺少长期随访的大规模出生队列。大型普通人群亲子前瞻性队列——广州出生队列(BIGCS)于2012年正式启动,对参与家庭从孕期到子代开展长期纵向观察。本队列以面对面的随访形式在孕早期、孕中期、孕晚期、分娩时,以及子代出生后6周、6个月、1岁、2岁、3岁、6岁、8.5岁等多个时点采集数据信息和生物样本,计划对队列儿童随访至18岁。截至2024年6月,广州出生队列入组超过6.0万名孕妇,儿童5.3万人,6岁儿童人数超过2.7万人,累积生物样本超过290万人份。其主要目标是发现影响妇女和儿童健康的危险因素,探讨其作用机理,验证系列不良妊娠结局和儿童期疾病的病因假设,为改善儿童和妇女健康的策略制定提供科学依据。本文将对广州出生队列的建设概况、研究进展以及未来发展方向做简要介绍。Birth cohorts are important research tools and resources for exploring the impacts of early life risk factors on offspring’s health throughout their life courses.However,large-scale birth cohorts with long-term follow-up are lack in China.The Born in Guangzhou Cohort Study(BIGCS),a large general-population parent-child prospective cohort,was officially launched in 2012 to conduct long-term longitudinal observation of participating families from pregnancy to offspring.This cohort collected data and biological samples through face-to-face follow-up at multiple time points,including early pregnancy,mid-pregnancy,late pregnancy,delivery,as well as 6 weeks,6 months,1 year,2 years,3 years,6 years,and 8.5 years after birth.Cohort children were planned to be followed up to 18 years of age.Up to June 2024,the BIGCS has recruited over 60000 pregnant women and 53000 children,among whom 27000 children are over 6 years old,with over 2.9 million specimens.The aim of this study is to identify the risk factors associated with adverse maternal and children’s health outcomes and explore their potential mechanisms and provide scientific evidences for developing the strategies to improve women and children’s health.This paper will give a brief introduction to the establishment,research progress,and future development of the BIGCS.

关 键 词：广州出生队列 妊娠 儿童 

分 类 号：R174[医药卫生—妇幼卫生保健]