基于正交试验设计-组合赋权TOPSIS法的菟丝子酒炙工艺优化  

Optimization of Rice Wine Processing Technology of Tusizi(Cuscutae Semen)Based on Orthogonal Experimental Design-Combination Weighting TOPSIS Method

作　　者：张秀如 杨金平[2] 焦春梅 崔雅晴 张翠翠 于明[1] 林慧彬[5] ZHANG Xiuru;YANG Jinping;JIAO Chunmei;CUI Yaqing;ZHANG Cuicui;YU Ming;LIN Huibin(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Binzhou People’s Hospital,Binzhou 256610,China;Pingyin Branch of Shandong Agricultural Radio and Television School,Jinan 250499,China;Shandong Pharmaceutical Industry Association,Jinan 250013,China;Shandong Academy of Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]滨州市人民医院,山东滨州256610 [3]山东省农业广播电视学校平阴分校,山东济南250499 [4]山东省医药行业协会,山东济南250013 [5]山东省中医药研究院,山东济南250014

出　　处：《山东中医药大学学报》2024年第5期596-602,共7页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(编号:2017YFC1701500);山东省科技型中小企业创新能力提升工程(编号:2022TSGC1059);中央本级重大增减支项目(编号:2060302)。

摘　　要：目的:优选菟丝子酒炙炮制工艺,为规范酒菟丝子炮制工艺提供参考。方法:基于L9(34)正交试验设计,以饮片外观性状、金丝桃苷含量、总黄酮含量、醇溶性浸出物含量为指标,以加酒量(A)、闷润时间(B)、炒制温度(C)、炒制时间(D)为考察因素,采用层次分析法(AHP)结合熵权法的组合赋权方式计算综合评分,利用逼近理想解排序(TOPSIS)模型筛选出酒菟丝子炮制的最佳工艺参数并进行工艺验证。结果:筛选出最优炮制工艺为生药材加10%黄酒,闷润6 h,炒炙温度为300℃,炒炙10 min。结论:运用正交试验设计-组合赋权TOPSIS法优选菟丝子酒炙工艺,结果简便、准确、可行。Objective:To optimize the rice wine processing technology of Tusizi(Cuscutae Semen),to provid a reference for regulating the rice wine processing technology of Tusizi.Methods:Based on the L9(34)orthogonal experimental design,the appearance properties,hypericin content,total flavone content and alcohol-soluble extract content of the decoction pieces were taken as indicators,and the amount of rice wine(A),moistening time(B),roasting temperature(C)and roasting time(D)were taken as factors.The comprehensive score was calculated using the combination weighting method of analytic hierarchy process(AHP)and entropy weight method.The optimal rice wine processing parameters of Tusizi were selected and verified by technique for order preference by similarity to an ideal solution(TOPSIS)model.Results:The optimum processing technology was as follows:raw medicinal material of Tusizi was added with 10%rice wine,moistened for 6 h,with roasting temperature 300℃and roasting time 10 min.Conclusion:The method of orthogonal experimental design and combination weighting TOPSIS method was used to optimize the rice wine processing technology of Tusizi.The results were simple,accurate and feasible.

关 键 词：酒菟丝子 正交试验 组合赋权 逼近理想解排序模型 工艺优化 

分 类 号：R283.3[医药卫生—中药学]