汉防己甲素抗病毒及抗炎作用研究进展  

Research Progress on Antiviral and Anti-inflammatory Effects of Tetrandrine

作　　者：李文倩 焦园园 杨稳 王明宇 齐冬梅[1] 王晓龙[1] 邢雅玲 王升启 LI Wenqian;JIAO Yuanyuan;YANG Wen;WANG Mingyu;QI Dongmei;WANG Xiaolong;XING Yaling;WANG Shengqi(Innovation Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Bioinformatics Center of Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]山东中医药大学中医药创新研究院,山东济南250355 [2]军事科学院军事医学研究院生物信息中心,北京100850

出　　处：《山东中医药大学学报》2024年第5期635-642,共8页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81830101)。

摘　　要：研究国内相关文献,概述汉防己甲素在抑制严重急性呼吸系统综合征冠状病毒Ⅱ型、猪流行性腹泻病毒、登革热病毒等方面的作用,以及其在风湿免疫系统、呼吸系统、神经系统、消化系统等疾病中的抗炎作用等。总结发现,汉防己甲素可以作为双孔通道拮抗剂抑制病毒进入和抑制病毒复制发挥抗病毒作用,还可以通过调控核转录因子蛋白家族(NF-κB)、Janus激酶信号转导和转录激活因子(JAK-STAT)、环氧化酶-2/前列腺素E2(COX-2/PGE2)、Nod样受体蛋白3(NLRP3)等相关信号通路调控炎症因子产生,调节机体抗病毒免疫,从而发挥抗炎和抗病毒的作用。重点分析了汉防己甲素对冠状病毒、埃博拉病毒等多种病毒的干预作用及机制,以及其发挥抗炎作用所涉及到的机制,旨在为今后对汉防己甲素进行深入的药用研究与应用提供参考。参考文献70篇。This paper reviewed the domestic and foreign research literature on the anti-viral effects of tetrandrine on coronavirus type II of severe acute respiratory syndrome,porcine epidemic diarrhea virus and dengue virus,as well as its anti-inflammatory effects on rheumatic immune system,the respiratory system,nervous system,digestive system,and other diseases.It was concluded that tetrandrine can act as a two-pore channel antagonist to inhibit the entry and replication of the virus to play an antiviral role.It can also regulate the production of inflammatory factors by regulating nuclear transcription factor-κB(NF-κB),Janus kinase signal transduction and activator of transcription(JAK-STAT),cyclooxygenase/prostaglandin E2(COX/PGE2),Nod-like receptor protein 3(NLRP3)and other related signaling pathways,and further regulate the antiviral immunity of the body.Ultimately,it exerts anti-inflammatory and antiviral effects.This paper mainly analyzed the intervention effect and mechanism of tetrandrine on coronavirus,Ebola virus and other viruses,as well as the mechanism involved in its anti-inflammatory effect,aiming to provide reference for further medicinal research and application of tetrandrine in the future.There are 70 references in total.

关 键 词：汉防己甲素 抗病毒 抗炎 双孔通道拮抗剂 内溶酶体 系统疾病 炎症 

分 类 号：R282.710.7[医药卫生—中药学]