PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity  

作　　者：Meihan Gong Ye Yuan Zhongye Dai Xuejiao Lv Jiacheng Su Dawei Huo Lin Niu Xu Chen Xudong Wu 

机构地区：[1]State Key Laboratory of Experimental Hematology,The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics,Key Laboratory of Immune Microenvironment and Disease(Ministry of Education),Department of Cell Biology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China [2]Bone Marrow Transplantation Center,the First Affiliated Hospital,Zhejiang University School of Medicine,Liangzhu Laboratory,Institute of Hematology,Zhejiang University,Hangzhou 311113,China

出　　处：《Science China(Life Sciences)》2024年第9期2033-2035,共3页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(32320103009,31970579);the National Youth Talent Support Program。

摘　　要：Dear Editor,Polycomb group proteins,conserved epigenetic transcriptional repressors,are crucial for orchestrating diverse developmental gene expression programs(Schuettengruber et al.,2017).The polycomb repressive complex 2(PRC2)catalyzes H3 lysine-27 trimethylation(H3K27me3)to establish a delicate balance with H3K4me3,forming a bivalent chromatin state at target gene promoters and thereby poising them for subsequent transcription activation(Bernstein et al.,2006).

关 键 词：valent thereby subsequent 

分 类 号：Q75[生物学—分子生物学]