Variant PRC1 subunit RYBP/YAF2 forms condensate with RING1B and promotes H2AK119ub deposition  

作　　者：Yanjiang Liu Gongcheng Hu Shengxiong Yang Chenghong Yan Juehan Wang Guangjin Pan Hongjie Yao 

机构地区：[1]State Key Laboratory of Respiratory Disease,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510530,China [2]Department of Basic Research,Guangzhou National Laboratory,Guangzhou 510005,China [3]CAS Key Laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China(Life Sciences)》2024年第9期2036-2038,共3页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31925009,U21A20195);the National Key Research and Development Program of China(2021YFA1100300)。

摘　　要：Dear Editor,Polycomb group(Pc G)proteins represent important roles in repressing gene expression throughout development.The Polycomb repressive complexes(PRCs)have been subdivided into two central protein complexes,PRC1 and PRC2.PRC1 catalyzes H2AK119ub and PRC2catalyzes H3K27me1/2/3(Fursova et al.,2019).PRC1 is further categorized as CBX-containing canonical PRC1(c PRC1)and RYBP/YAF2-containing variant PRC1(v PRC1)(Blackledge and Klose,2021).

关 键 词：PRC1 RING1 RYBP 

分 类 号：Q132[生物学—普通生物学]