Nickel-catalyzed arylcyanation of alkenes via cyano group translocation:access to 1,n-dinitriles or 4-amino nitriles  

作　　者：Xiaohong Li Shenfan Wang Xiangxiang Fu Donghui Xing Zeyuan Fu Yuanfu Deng Huanfeng Jiang Liangbin Huang 

机构地区：[1]State Key Laboratory of Pulp and Paper Engineering,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China

出　　处：《Science China Chemistry》2024年第9期2975-2981,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21971074,22001076);the Natural Science Foundation of Guangdong Province(2022A1515010660,2021A1515220024);the Natural Science Foundation of Guangzhou(202102020982)。

摘　　要：Herein,a nickel-catalyzed arylcyanation of unactivated alkenes via cyano group translocation with aryl boronic acids has been developed.These transformations provided a robust approach to constructing structurally diverse 1,n-dinitriles or 4-amino nitriles from easily prepared and commercially available starting materials.The cyano group translocation was achieved,involving the addition into the intramolecular C–N triple bond followed by the retro-Thorpe reaction.Mechanistic studies revealed that high temperature and CsHCO_(3) as the base were crucial for the cyano group translocation.

关 键 词：arylcyanation nickel catalysis cyano group translocation 1 n-dinitriles 4-amino nitriles 

分 类 号：O621.251[理学—有机化学]