Decarboxylative cyanation and thiocyanation via catalytic electron donor-acceptor complex with copper catalysis  

作　　者：Hongping Zhao Xiaoxiang Xi Tianbao Wu Zimin Chen Minyan Wang Weiming Yuan 

机构地区：[1]Key Laboratory of Material Chemistry for Energy Conversion and Storage,Ministry of Education,Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology(HUST),Wuhan 430074,China [2]State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China [3]Shenzhen Huazhong University of Science and Technology Research Institute,Shenzhen 518000,China

出　　处：《Science China Chemistry》2024年第9期3019-3028,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22201087);the National Key R&D Program of China(2022YFA1503200);Guangdong Basic and Applied Basic Research Foundation(2022A1515012507)。

摘　　要：A new catalytic decarboxylative cyanation and thiocyanation via a synergistic Na I/Cu catalysis is developed.The photoexcited electron donor-acceptor complex by assembly of Na I,R3P,and N-acyloxy-phthalimide ester(NHPI ester)triggers the generation of alkyl radical species,which then engages in Cu-catalyzed radical coupling process.Key to success of this dual catalytic transformation is the reliable charge transfer between I·and Cu(I).This dual catalytic platform can eliminate the use of expensive iridium-based photocatalyst or synthetically elaborate organic dyes.A series of primary,secondary,and tertiary alkyl nitriles and thiocyanates are easily synthesized.Moreover,an asymmetric decarboxylative cyanation by applying a chiral Cu catalyst is also developed to afford chiral nitriles in high enantioselectivity.The mechanistic details and the origin of the high enantioselectivity are further investigated by the mechanistic experiments and the density functional theory calculations.

关 键 词：electron donor-acceptor catalysis copper catalysis CYANATION THIOCYANATION asymmetric synthesis 

分 类 号：O621.251[理学—有机化学]