高原习服与适应的评估模型构建  

Evaluation model of acclimatization and adaptation at high altitude

作　　者：李昊 刘晓彤 吴怡璠 王琳 苏瑞 马海林[1] Hao Li;Xiaotong Liu;Yifan Wu;Lin Wang;Rui Su;Hailin Ma(Key Laboratory of High Altitudes Brain Science and Environmental Acclimation,Tibet University,Lhasa 850000,China)

机构地区：[1]西藏大学高原脑科学与环境习服重点实验室,拉萨850000

出　　处：《科学通报》2024年第24期3628-3641,共14页Chinese Science Bulletin

基　　金：国家自然科学基金(U23A20476,32260212);西藏自治区人口与健康重大科技专项子课题(XZ202201ZD0001G);西藏自治区重点研发项目(2023ZYJM001)资助。

摘　　要：本研究旨在分析SpO_(2)/HCT比值作为高原习服性评估指标对高原习服与适应的预测价值.收集了西藏自治区某医院2347名接受常规体检的患者体检报告,并由高原病研究专家根据患者体检报告和问诊结果,将患者分为高原习服性组和高原不习服组.采用SpO_(2)/HCT指标作为高原习服性评估指标,并对两组进行比较.同时,分析高原习服性评估指标与慢性高原病(chronic mountain sickness,CMS)之间的相关性.使用受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)来评估高原习服性评估指标对高原习服良好与不良人群的诊断效能.通过SpO_(2)/HCT指标与世居者生理生化指标的关联,证明了SpO_(2)/HCT比值评估的准确性.本研究确认,SpO_(2)/HCT指标(altitude acclimatization/adaptation index,AAI)能够有效评估个体在高原的习服和适应水平.AAI=1.7228被确定为高原习服和适应的临界值,小于1.7228表示习服和适应不良,而大于等于1.7228表示习服和适应良好.AAI适用于高海拔移居者和世居者的高原习服或适应程度评估.The research aim was to delve into the nuanced realm of high-altitude acclimatization and adaptation,focusing primarily on the predictive efficacy of the SpO_(2)/HCT ratio as a key indicator.Drawing from a robust dataset comprising medical examination reports from 2347 patients undergoing routine check-ups at a hospital situated in the Xizang Autonomous Region,researchers sought to unravel the intricate dynamics of physiological adjustments at elevated altitudes.Highaltitude medicine experts,armed with their specialized knowledge,meticulously categorized the diverse patient pool into distinct groups based on acclimatization status.This demarcation led to the identification of two cohorts:Individuals adept at acclimating to high altitudes and those grappling with challenges in adaptation.The SpO_(2)/HCT ratio played a pivotal role as the chosen metric for assessing acclimatization,setting the stage for a comparative analysis between the two groups.Simultaneously,the correlation between the selected acclimatization indicator,the SpO_(2)/HCT ratio,and the prevalence of chronic mountain sickness(CMS),was explored.This multifaceted approach aimed to unravel potential connections between acclimatization levels and the manifestation of chronic health issues in high-altitude environments.To bolster the robustness of the findings,the researchers employed such sophisticated analytical tools as the receiver operating characteristic(ROC)curve analysis and the area under the curve(AUC)calculator.These methodologies were harnessed to scrutinize the diagnostic performance of the SpO_(2)/HCT ratio in discerning individuals with varying degrees of acclimatization to the challenges posed by high altitudes.Further fortifying the study’s foundation,an in-depth exploration of the association between the SpO_(2)/HCT ratio and the physiological and biochemical indicators of long-term high-altitude residents was conducted.The aim of this holistic approach was to validate the accuracy of the SpO_(2)/HCT ratio as a reliable assessment t

关 键 词：高原习服 高原适应 评估 血氧饱和度 红细胞压积 

分 类 号：R339.5[医药卫生—人体生理学]