Ru(Ⅱ)-Catalyzed Selective C-H Alkynylation of Isoquinolones,Quinazolones and Phthalazinones with Bromoalkynes  

作　　者：Quan-Jian Luo Han-Chi Wang Jing Zhang Jin-Heng Li Bo Sun 

机构地区：[1]State Key Laboratory Base of Eco-Chemical Engineering,College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China [2]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

出　　处：《Chinese Journal of Chemistry》2024年第15期1686-1690,共5页中国化学（英文版）

基　　金：supported by the Natural Science Foundation of Shandong Province(ZR2019BB011);the Scientific Research Foundation of Qingdao University of Science&Technology(010029022).

摘　　要：A new,selective Ru(Ⅱ)-catalyzed alkynylation reaction of isoquinolones,quinazolones and phthalazinones with readily available bromoalkynes has been developed.This reaction enables the selective construction of a new C(sp^(2))-C(sp)bond through C-H activation and C-Br functionalization,and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone,quinazolone and phthalazinonederivatives with a wide substrate scope and highselectivity.

关 键 词：Ru(Ⅱ) ALKYNYLATION Isoquinolones Bromoalkynes Heterocyclic compounds C-H activation C-C coupling Synthetic methods 

分 类 号：O64[理学—物理化学]