Yeast-Controlled Double-Shelled CacO_(3)/CaF_(2)Hollow Nanospheres with Hierarchically Porous for Sustained pH-Sensitive Drug Release  

作　　者：Xinhe Liu Yi Chang Guanglei Ma Tingting Liu Penghui Song Heng Yu Xueqing Ren Yuming Guo Xiaoming Ma 

机构地区：[1]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China [2]Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals,Key Laboratory of Green Chemical Media and Reactions,Ministryof Education,Henan Normal University,Xinxiang,Henan 453007,China

出　　处：《Chinese Journal of Chemistry》2024年第15期1713-1720,共8页中国化学（英文版）

基　　金：financially supported by the Natural Science Foundation of Henan Province of China(Key Program,No.242300421205);the National Natural Science Foundation of China(21877027,21771058,and 21601052);Key Science and Technology Project of Henan Province(232102310223);Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTITO02);Natural Science Foundation of Henan(212300410009);the Program for Innovative Research Team in Science and Technology in Universities of Henan Province(19IRTSTHNO23).

摘　　要：Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of biomedicine.However,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great challenge.Herein,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast cells.The biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable biocompatibility.The double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical pores.Otherwise,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor microenvironment.Both in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic effect.Summarily,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.

关 键 词：Biomimetic synthesis Hierarchically porous Sustained pH-sensitive drug release Antitumor agents Drug delivery Calcium Cancer therapy/Hollow structures 

分 类 号：TB383[一般工业技术—材料科学与工程]