铁死亡在睾丸中的研究进展  

Ferroptosis in the testis:Progress in research

作　　者：张文秀 孙大林[2] 金保方[2] ZHANG Wen-xiu;SUN Da-lin;JIN Bao-fang(Qinghai University,Xining,Qinghai 810016,China;Andrology Department of Integrative Medicine,Zhongda Hospital,Southeast University,Nanjing,Jiangsu 210009,China)

机构地区：[1]青海大学,青海西宁810016 [2]东南大学附属中大医院中西医结合男科,江苏南京210009

出　　处：《中华男科学杂志》2024年第7期663-667,共5页National Journal of Andrology

基　　金：国家自然科学基金(82374459)。

摘　　要：铁死亡是细胞内铁代谢紊乱,脂质过氧化物过多积累导致细胞死亡的形式。研究表明,在不同致病因素的影响下,铁死亡通过不同的通路及分子影响睾丸激素的合成,调控细胞功能,对男性生殖系统及男性生育力有着很大的影响。本文就铁死亡在男性睾丸中的作用机制及致病相关性的研究进行综述,为男性生殖系统疾病的治疗提供新的思路。Ferroptosis is a form of cell death resulting from the disruption of iron metabolism within cells and excessive accumulation of lipid peroxides.Research indicates that,under the influence of various pathogenic factors,ferroptosis impacts the male reproductive system and fertility by affecting the synthesis of testicular hormones and regulation of cellular functions through different pathways and numerators.This paper provides an overview of the action mechanisms of ferroptosis in the testis and its correlation with pathogenicity,offering some new insights into the treatment of male reproductive system diseases.

关 键 词：铁死亡 睾丸 细胞死亡 氧化应激 高危因素 

分 类 号：R588.1[医药卫生—内分泌]