醋酸卡泊芬净生产工艺的技术改进  

Technical Improvement of the Production Process of Caspofungin Acetate

作　　者：焦守峰[1] 董宏皎 陈娜 翟亚东 Jiao Shoufeng;Dong Hongjiao;Chen Na;Zhai Yadong(Huaibei Vocational and Technical College,Huaibei 235000,China;Linhuan Coking Co.,Ltd.,Huaibei 235000,China)

机构地区：[1]淮北职业技术学院,安徽淮北235000 [2]临涣焦化股份有限公司,安徽淮北235000

出　　处：《广东化工》2024年第15期4-6,共3页Guangdong Chemical Industry

基　　金：安徽省科研研究项目-重点项目(2023AH052868)。

摘　　要：介绍了醋酸卡泊芬净制备过程,通过小试探索对主流工艺进行改进,通过丙酮打浆、溶剂洗涤、一锅法合成卡泊芬净醋酸水溶液、氮气干燥等工艺技术改进,实现了工业化公斤级生产并且成功完成了工业公斤级别的工艺放大,极大地降低了产业的生产成本,提高了产品合成收率,可以为更大级别的工业生产放大提供一定的技术支撑。The preparation process of caspofungin acetate was introduced,and the mainstream process was improved through pilot study.Through technological improvements such as acetone pulping,solvent washing,one pot synthesis of carbofuran acetate aqueous solution,nitrogen drying,etc.,achieve industrial kilogram level production and successfully achieve industrial metric level process amplification,which greatly reduced the production cost of the industry,and can provide certain technical support for larger industrial production amplification.

关 键 词：醋酸卡泊芬净 工艺改进 公斤级 生产放大 一锅法 

分 类 号：TQ[化学工程]