胎儿分数预测胎盘源性疾病的研究进展  

Progress in fetal fraction prediction of placental diseases

作　　者：李姗姗 李雯[1,2] 卫卓 申永梅 赵晓敏 姚立英[1,3] 常颖[1,2,3] Li Shanshan;Li Wen;Wei Zhuo;Shen Yongmei;Zhao Xiaomin;Yao Liying;Chang Ying(Tianjin Central Hospital of Obstetrics and Gynecology/Nankai University Affiliated Maternity Hospital,Tianjin 300100,China;Tianjin Key Laboratory for Human Development and Reproductive Regulation/Tianjin Institute of Obstetrics and Gynecology,Tianjin 300100,China;Prenatal Diagnosis Center,Tianjin Central Hospital of Obstetrics and Gynecology,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院/南开大学附属妇产医院,天津300100 [2]天津市人类发育与生殖调控重点实验室/天津市妇产科研究所,天津300100 [3]天津市中心妇产科医院产前诊断中心,天津300100

出　　处：《中华医学遗传学杂志》2024年第9期1032-1038,共7页Chinese Journal of Medical Genetics

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-043A);天津市卫健委项目(ZD20022、TJWJ2021QN052);天津市自然科学基金(21JCQNJC00040);天津市人类发育与生殖调控重点实验室开放基金(2021XH04、2022XH04)。

摘　　要：胎盘源性疾病可能影响妊娠结局以及母儿的远期健康。胎儿分数是无创产前检测是否成功的关键指标。胎儿分数与孕周、体质量指数、染色体非整倍体疾病等相关。多项研究发现胎儿分数与胎盘源性疾病相关,有可能成为该类疾病新的预测因子。本文就二者的关系进行了归纳和整理,以期为胎盘源性疾病的预测提供新的思路。Placental diseases may affect the outcome of pregnancy and long-term health of the mother and fetus.Fetal fraction is a key indicator for the success of non-invasive prenatal testing,and has been associated with gestational age,body mass index and fetal chromosomal aneuploidies.Many studies have found that fetal fraction is also related to placenta-derived diseases and may become a new predictor for such diseases.This article has summarized the association between the two,with an aim to provide new ideas for the prediction of placental diseases.

关 键 词：胎盘源性疾病 胎儿分数 预测 妊娠结局 

分 类 号：R714.5[医药卫生—妇产科学]