妊娠期高血压疾病患者血清及脐血中TGF-β1、Endoglin表达水平及临床意义  

Expression levels and clinical significance of TGF-β1 and Endoglin in serum and umbilical cord blood of patients with hypertensive disorder complicating pregnancy

作　　者：金鑫 谭芳芳 丁艳歌 王艳 朱锦明 JIN Xin;TAN Fangfang;DING Yange;WANG Yan;ZHU Jinming(Department of Obstetrics and Gynecology,The First Clinical Medical College of Xuzhou Medical University,Xuzhou Jiangsu 221000;Department of Obstetrics and Gynecology,Pizhou Hospital,Xuzhou Medical University,Pizhou Jiangsu 221300;Department of Obstetrics and Gynecology,Xuzhou Maternal and Child Health Hospital,Xuzhou Jiangsu 221399,China)

机构地区：[1]徐州医科大学第一临床医学院,江苏徐州221000 [2]徐州医科大学附属徐州妇幼保健院产科,江苏邳州221300 [3]徐州医科大学附属邳州医院妇产科,江苏徐州221399

出　　处：《中国妇产科临床杂志》2024年第5期445-448,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：江苏省卫生健康委科研项目(M2020100)。

摘　　要：目的探究妊娠期高血压疾病患者血清及脐血中转化生长因子-β1(TGF-β1)、Endoglin表达水平及临床意义。方法回顾性分析2020年2月至2023年4月徐州医科大学附属邳州医院收治的148例妊娠期高血压疾病患者的临床资料,将其设为观察组(n=148),选择本院同期收治的109例正常妊娠期女性为对照组(n=109)。比较两组的血清、脐血中TGF-β1、Endoglin水平差异,使用受试者特征(ROC)曲线分析血清指标的诊断价值。将观察组患者根据疾病的严重程度分为妊娠期高血压组(n=64)及子痫前期组(n=84),比较两组患者的血清、脐血中TGF-β1、Endoglin的水平差异,分析血清指标对严重程度的诊断价值。结果观察组患者血清中TGF-β1、Endoglin及脐血中Endoglin水平均高于对照组(P<0.05);两组的脐血TGF-β1水平比较,差异无统计学意义(P>0.05);ROC曲线显示,血清中TGF-β1、Endoglin诊断妊娠期高血压疾病的AUC分别为0.830、0.711(P<0.05);子痫前期组患者血清、脐血中TGF-β1和Endoglin水平均高于妊娠期高血压组患者(P<0.05);ROC曲线显示,血清中TGF-β1、Endoglin诊断妊娠期高血压疾病严重程度的AUC分别为0.808、0.905(P<0.05)。结论TGF-β1、Endoglin表达水平的变化与妊娠期高血压疾病的发生、发展存在联系。Objective To explore the expression levels and clinical significance of transforming growth factor-β1(TGF-β1)and Endoglin in serum and umbilical cord blood of patients with hypertensive disorder complicating pregnancy(HDCP).Methods The clinical data of 148 patients with HDCP admitted from February 2020 to April 2023 were retrospectively analyzed in the Pizhou Hospital of Xuzhou Medical University,and the patients were set as observation group(n=148),and normal pregnant women were included in control group(n=109).The differences in TGF-β1 and Endoglin in serum and umbilical cord blood were compared between both groups of patients.ROC curve was applied to analyze the diagnostic value of serum indicators.The patients in the observation group were classified into gestational hypertension group(n=64)and preeclampsia group(n=84)by adopting disease severity,and the levels of TGF-β1 and Endoglin in serum and umbilical cord blood were compared.The diagnostic value of serum indicators on the severity was analyzed.Results The levels of TGF-β1 and Endoglin in serum and Endoglin in umbilical cord blood in observation group were higher than those in control group(P<0.05),but there was no statistical significance in umbilical cord blood TGF-β1 level between the two groups(P>0.05).ROC curve showed that the AUCs of serum TGF-β1 and Endoglin in the diagnosis of hypertensive disorder complicating pregnancy were 0.830 and 0.711 respectively(P<0.05).The levels of TGF-β1 and Endoglin in serum and umbilical cord blood in preeclampsia group were higher than those in gestational hypertension group(P<0.05).ROC curve revealed that the AUCs of serum TGF-β1 and Endoglin in diagnosing the severity of hypertensive disorder complicating pregnancy were 0.808 and 0.905(P<0.05).Conclusion The changes of expression levels of TGF-β1 and Endoglin are related to the occurrence and development of hypertensive disorder complicating pregnancy.

关 键 词：妊娠期高血压疾病 转化生长因子-Β1 ENDOGLIN 妊娠 

分 类 号：R714.246[医药卫生—妇产科学]