活性氧清除性水凝胶在骨关节炎治疗中的研究进展  

Research progress of reactive oxygen scavenging hydrogel in osteoarthritis

作　　者：黄鹏飞 赵俊杰[1] 张兆坤 王玺玉 赵宇昊 赵海燕[2] Huang Pengfei;Zhao Junjie;Zhang Zhaokun;Wang Xiyu;Zhao Yuhao;Zhao Haiyan(The first school of clinical medicine,Lanzhou university,Lanzhou 730000,China;Department of Orthopaedics,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院骨科,兰州730000

出　　处：《中华骨科杂志》2024年第17期1184-1190,共7页Chinese Journal of Orthopaedics

基　　金：国家自然科学基金项目(82060394);兰州市人才创新创业项目(2020-RC-45);兰州大学第一医院院内基金(ldyyyn2022-73)。

摘　　要：活性氧在维持机体代谢平衡中扮演着十分重要的角色,不仅是维持正常生理环境重要的介质,也是导致诸多疾病发生发展的重要诱因。骨关节炎是目前最常见的退行性关节疾病,由于人口老龄化、预期寿命延长、肥胖等原因,骨关节炎的发病率和患病率逐年增加,近年来对骨关节炎的研究表明,活性氧在其发生和发展中起着至关重要的作用,是导致细胞外基质降解、线粒体功能障碍、软骨细胞凋亡以及骨关节炎进展的关键因素。对骨关节炎而言,适量的活性氧可以促进软骨细胞的增殖和软骨基质的形成。但过量的活性氧累积会诱导氧化应激,引起软骨细胞退化及软骨基质的分解,最终导致骨关节炎以及其他诸多代谢性疾病的发生。近年来,水凝胶作为新型生物材料治疗骨关节炎备受关注,活性氧清除性水凝胶是一种可以调节组织氧化应激和炎症反应的一种具有药物智能递送功能的新型高分子生物材料,主要包括以负载活性氧清除性药物为主要功能的传统活性氧清除性水凝胶和具有活性氧响应性基团的活性氧响应性水凝胶。前者主要以缓释其包封的具有活性氧清除性的药物治疗骨关节炎,而后者不仅可以通过活性氧响应性基团断裂清除骨关节炎发生发展过程中产生的活性氧,还可以响应性递送多种治疗骨关节炎的药物。活性氧清除性水凝胶在治疗骨关节炎修复领域展望出良好的应用前景。Reactive oxygen species play a crucial role in maintaining metabolic balance in the body.They are not only im-portant mediators in maintaining a normal physiological environment,but also important triggers for the occurrence and development of many diseases.Osteoarthritis is the most common degenerative joint disease at present.Due to the aging population,extended life expectancy and obesity,the incidence rate and prevalence of osteoarthritis have increased year by year.Recent studies on osteoarthri-tis show that reactive oxygen species play a crucial role in its occurrence and development,and are key factors leading to extracellu-lar matrix degradation,mitochondrial dysfunction,chondrocyte apoptosis and the progress of osteoarthritis.For osteoarthritis,moder-ate levels of reactive oxygen species can promote the proliferation of chondrocytes and the formation of cartilage matrix.However,ex-cessive accumulation of reactive oxygen species can induce oxidative stress,leading to degeneration of chondrocytes and breakdown of cartilage matrix,ultimately resulting in the occurrence of osteoarthritis and many other metabolic diseases.In recent years,hydro-gels have attracted attention as new biomaterials for the treatment of osteoarthritis.Reactive oxygen scavenging hydrogels are a new type of polymer biomaterials with drug intelligent delivery function that can regulate tissue oxidative stress and inflammatory reaction.They mainly include traditional reactive oxygen scavenging hydrogels with the main function of loading reactive oxygen scavenging drugs and reactive oxygen responsive hydrogels with reactive oxygen responsive groups.The former mainly uses slow-release drugs with reactive oxygen species scavenging properties encapsulated in it to treat osteoarthritis,while the latter can not only clear the reac-tive oxygen species generated during the occurrence and development of osteoarthritis by breaking the reactive oxygen species respon-sive groups,but also responsively deliver various drugs for treating osteoarthriti

关 键 词：骨关节炎 活性氧 生物相容性材料 水凝胶类 氧化应激 

分 类 号：R684.3[医药卫生—骨科学]