尿中挥发性有机物作为肺癌诊断生物标志物的研究进展  

Research progress of urinary volatile organic compounds as diagnostic biomarkers for lung cancer

作　　者：郭维静[1] 蒋吉春 魏麟欢[1] 李倩[1] 赵丹[1] 杨丽君[1] GUO Wei-jing;JIANG Ji-chun;WEI Lin-huan;LI Qian;ZHAO Dan;YANG Li-jun(Dalian Center for Disease Control and Prevention,Dalian 116035,China;CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences)

机构地区：[1]大连市疾病预防控制中心,大连116035 [2]中国科学院分离分析化学重点实验室,中国科学院大连化学物理研究所

出　　处：《环境卫生学杂志》2024年第8期700-708,共9页JOURNAL OF ENVIRONMENTAL HYGIENE

摘　　要：肺癌是世界范围内最常见的恶性肿瘤之一,早期的诊断对患者的治疗和预后至关重要。近年来,代谢组学中尿液挥发性有机物作为肺癌的潜在诊断标志物备受关注。该综述旨在总结近年来采用质谱技术检测的尿中挥发性有机物作为肺癌诊断标志物的研究进展,并探讨其潜在应用前景。Lung cancer is one of the most common malignant tumors in the world,and early diagnosis is crucial to the treatment and prognosis of patients.In recent years,researchers in metabolomigcs have increasingly focused on volatile organic compounds in urine as potential diagnostic markers for lung cancer.The purpose of this review is to summarize the research progress of detecting volatile organic compounds in urine as a diagnostic marker for lung cancer in recent years,and to explore its potential application prospects.

关 键 词：挥发性有机物 尿液 肿瘤标志物 代谢组学 肺癌 

分 类 号：R11[医药卫生—公共卫生与预防医学] R73