相控射频微针联合米诺环素治疗中重度痤疮的临床疗效  

Clinical Efficacy of Phase Controlled Radiofrequency Microneedle Combined with Minocycline for the Treatment of Moderate to Severe Acne

作　　者：郭敏 高明 李文璐 GUO Min;GAO Ming;LI Wenlu(Hunan Yueji Medical Cosmetology Co.,LTD.Yuhua Yueji Medical Cosmetology Outpatient Department,Changsha Hunan 410007)

机构地区：[1]湖南悦己医疗美容有限公司雨花悦己医疗美容门诊部,湖南长沙410007

出　　处：《医学临床研究》2024年第8期1152-1155,共4页Journal of Clinical Research

摘　　要：【目的】探讨相控射频微针联合米诺环素治疗中重度痤疮的临床疗效。【方法】选取2022年7月至2023年12月在本门诊就诊的60例中重度痤疮患者,按照随机数字表法分为观察组(采用相控射频微针联合米诺环素治疗)和对照组(采用强脉冲光联合米诺环素治疗),每组30例。观察组采用相控射频微针联合米诺环素治疗,对照组采用强脉冲光联合米诺环素治疗,两组均为单次治疗。比较两组治疗前、治疗后1个月、治疗后3个月面部痤疮综合分级系统量表(global acne grading system,GAGS)评分及红斑、毛孔、紫质情况,比较两组治疗效果、不良反应发生情况。【结果】治疗后1个月,观察组有效率为93.33%,与对照组的86.67%比较,差异无统计学意义(P>0.05)。治疗后,两组GAGS评分均较治疗前下降,且观察组GAGS评分低于对照组(P<0.05)。治疗后,两组红斑、紫质、毛孔均较治疗前显著改善(P<0.05);且观察组红斑、毛孔改善程度优于对照组(P<0.05),但两组紫质百分率比较,差异无统计学意义(P>0.05)。所有患者均无明显不良反应发生。【结论】相控射频微针或强脉冲光联合米诺环素治疗中重度寻常型痤疮均安全、有效,但相控射频微针联合米诺环素对毛孔粗大、皮肤细腻度改善更显著。【Objective】To investigate the clinical efficacy of phased radiofrequency microneedling combined with minocycline in the treatment of moderate to severe acne.【Methods】Sixty patients with moderate to severe acne who visited our clinic from July 2022 to December 2023 were randomly divided into the observation group(treated with phased radiofrequency microneedle combined with minocycline)and the control group(treated with intense pulsed light combined with minocycline)using a random number table method,with 30 patients in each group.The observation group was treated with phase controlled radiofrequency microneedle combined with minocycline,while the control group was treated with intense pulsed light combined with minocycline.Both groups received single treatment.We compared the scores of the Global Acne Grading System(GAGS)and the conditions of erythema,pores,and amethyst between two groups before treatment,1 month after treatment,and 3 months after treatment.We also compared the treatment efficacy and incidence of adverse reactions between the two groups.【Results】One month after treatment,the effective rate of the observation group was 93.33%,which was not significantly different from the control group's 86.67%(P>0.05).After treatment,the GAGS scores of both groups decreased compared to before treatment,and the GAGS score of the observation group was lower than that of the control group(P<0.05).After treatment,both groups showed significant improvement in erythema,purple pigment,and pores compared to before treatment(P<0.05);And the improvement of erythema and pores in the observation group was better than that in the control group(P<0.05),but there was no statistically significant difference in the percentage of purple matter between the two groups(P>0.05).All patients had no significant adverse reactions.【Conclusion】The combination of phase controlled radiofrequency microneedles or intense pulsed light with minocycline is safe and effective in treating moderate to severe acne vulgaris.However,the

关 键 词：寻常痤疮/药物疗法 射频疗法 微针疗法 米诺环素/治疗应用 治疗结果 病人病情 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]