卡前列素氨丁三醇联合缩宫素治疗高危妊娠阴道分娩产后出血产妇的临床效果  

Clinical Efficacy of Carboprost Tromethamine Combined with Oxytocin in the Treatment of Postpartum Hemorrhage in high-risk Pregnant Women Undergoing Vaginal Delivery

作　　者：牛辉辉 韩利品 NIU Huihui;HAN Lipin(Department of Obstetrics and Gynecology,Luoyang Wuyiyi Sanbo Brain Hospital,Luoyang Henan 471000)

机构地区：[1]洛阳伍一一三博脑科医院妇产科,河南洛阳471000

出　　处：《医学临床研究》2024年第8期1185-1187,共3页Journal of Clinical Research

摘　　要：【目的】探讨卡前列素氨丁三醇联合缩宫素治疗高危妊娠阴道分娩产后出血产妇的临床效果。【方法】回顾性分析2019年2月至2023年2月本院收治的82例高危妊娠阴道分娩产后出血产妇的临床资料,按照治疗方法不同分为对照组(采用缩宫素治疗)和观察组(采用卡前列素氨丁三醇联合缩宫素治疗),每组41例。比较两组一般资料、临床疗效、产后不良反应发生率及产后1 h、3 h、9 h出血量,治疗前、治疗后15 min、治疗后1 h的子宫动脉收缩期峰值流速(PSV)、搏动指数(PI)。【结果】观察组总有效率高于对照组(P<0.05)。观察组产后3 h、9 h出血量低于对照组产后3 h、9 h的出血量(P<0.05)。与治疗前比较,两组治疗后15 min、治疗后1 h的PSV、PI均降低(P<0.05);观察组治疗后15 min、治疗后1 h的PSV高于对照组,PI低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】采用缩宫素联合卡前列素氨丁三醇治疗高危妊娠阴道分娩产后出血产妇的效果较好,可改善产妇血流动力学指标,且安全性高,值得临床推广应用。【Objective】To investigate the clinical efficacy of combining carboprost tromethamine with oxytocin in the treatment of postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery.【Methods】A retrospective analysis was conducted on the clinical data of 82 high-risk pregnant women with postpartum hemorrhage who underwent vaginal delivery in our hospital from February 2019 to February 2023.They were divided into the control group(treated with oxytocin)and the observation group(treated with carboprost tromethamine combined with oxytocin)according to different treatment methods,with 41 cases in each group.Two groups were compared in terms of general information,clinical efficacy,incidence of postpartum adverse reactions,bleeding volume at 1,3,and 9 hours postpartum,as well as peak systolic velocity(PSV)and pulsatility index(PI)of uterine arteries before treatment,15 minutes after treatment,and 1 hour after treatment.【Results】The total effective rate of the observation group was higher than that of the control group(P<0.05).The amount of bleeding in the observation group at 3 and 9 hours postpartum was lower than that in the control group at 3 and 9 hours postpartum(P<0.05).Compared with before treatment,both groups showed a decrease in PSV and PI at 15 minutes and 1 hour after treatment(P<0.05);The PSV of the observation group was higher than that of the control group at 15 minutes and 1 hour after treatment,and the PI was lower than that of the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】The use of oxytocin combined with carboprost tromethamine in the treatment of postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery is effective,can improve maternal hemodynamic indicators,and has high safety.It is worthy of clinical promotion and application.

关 键 词：自然分娩 产后出血/药物疗法 氨丁三醇 卡波前列素 催产素 

分 类 号：R714.461[医药卫生—妇产科学]