2004-2022年重庆市永川区丙型病毒性肝炎患者核酸阳性率及基因型特点分析  

Nucleic acid positive rate and genotype characteristics analysis among patients with viral hepatitis C in Yongchuan District of Chongqing city during 2004-2022

作　　者：吴欢 徐洁 李琴[1] 陈亮[1] 赵芬 蒋雪飞[1] WU Huan;XU Jie;LI Qin;CHENG Liang;ZHAO Fen;JIANG Xuefei(Yongchuan District Center for Disease Control and Prevention,Chongqing 402160,China)

机构地区：[1]重庆市永川区疾病预防控制中心,重庆402160

出　　处：《重庆医学》2024年第17期2668-2671,2681,共5页Chongqing Medical Journal

基　　金：重庆市科卫联合医学科研重点项目(2022ZDXM001);重庆市永川区自然科学基金重点项目(2023yc-jckx20069)。

摘　　要：目的分析2004-2022年重庆市永川区丙型病毒性肝炎(简称丙肝)患者的核酸阳性率和基因型特点。方法概率比例抽样法选取2004-2022年中国疾病预防控制信息传染病监测系统中录入的所有现住址为重庆市永川区的已审核在库管理的丙肝患者为研究对象,进行问卷调查、核酸和基因型检测,分析其核酸阳性率及基因型特点。结果调查的489例丙肝患者中检出丙型肝炎病毒核酸(HCV-RNA)阳性286例(58.49%);不同性别、职业、文化程度、医保类型的HCV-RNA阳性率比较差异有统计学意义(P<0.05),但不同年龄、婚姻状况、个人月均收入及常住地区HCV-RNA阳性率比较差异无统计学意义(P>0.05)。检出285例单一亚型感染和1例1b型和6a型混合亚型感染,单一亚型感染主要为1b型(56.45%)、3b型(12.94%)、6a型(12.94%)。结论2004-2022年重庆市永川区丙肝患者中超过一半比例的既往病例仍是现症感染者,需要接受抗病毒治疗。HCV基因型以1b型为主,其次为3b、6a型。要进一步动员既往丙肝患者治疗,提高治疗率和临床治愈率。Objective To analyze the nucleic acid positive rate and genotype characteristics of the patients with viral hepatitis C in Yongchuan District of Chongqing city during 2004-2022.Methods All the hepatitis C patients whose current address was in Yongchuan District of Chongqing City and audited for management entering in the database of the Infectious disease surveillance System of China Disease Prevention and Control Information from 2004 to 2022 were selected as the study subjects.The questionnaire survey,nucleic acid and genotype detection were conducted.The nucleic acid positive rate and genotype characteristics were analyzed.Results Among 489 cases of viral hepatitis C,there were 286 cases of hepatitis C viral nucleic acid(HCV-RNA)positive(58.49%),the positive rate of males was 64.63%,which was high than 49.23%in females,and the differences was statistically significant(P<0.05).The HCV-RNA positive rate had statistical difference among different professions,cultural levels and medical insurance types(P<0.05).But the HCV-RNA positive rates had no statistically difference among different ages,marital status,incomes and permanent residences(P>0.05).A total of 285 cases of single infection subtype and 1 case of 1b and 6a mixed subtype were detected out.The single infection subtypes were mainly the 1b type(56.45%),3b type(12.89%)and 6a type(13.24%).Conclusion The positive rate of HCV-RNA among hepatitis C patients in Yongchuan District during 2004-2022 was 58.49%,more than half of the previous cases are still the active infected persons requiring the antiviral treatment.The HCV genotype is mainly the 1b type,followed by 3a,3b and 6a types.It is necessary to further mobilize the treatment of previous patients with hepatitis C and improve the treatment rate and clinical cure rate.

关 键 词：丙型病毒性肝炎 核酸阳性率 治疗规模 基因型 

分 类 号：R183.7[医药卫生—流行病学]