基于本体推理和语义网检索的中西药相互作用知识发现研究  

Research on Knowledge Discovery of Traditional Chinese and Western Medicine Interaction Based on Ontology Reasoning and Semantic Web Retrieval

作　　者：杨乐乐 龙海[2] 姚克宇 刘丽红[1] 朱彦[1] YANG Lee;LONG Hai;YAO Keyu;LIU Lihong;ZHU Yan(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Medical Informatics,Statistics and Epidemiology(IMISE),ONTO-MED Research Group,University of Leipzig,Leipzig 04103,Germany)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]莱比锡大学医学信息统计学暨流行病学研究所ONTO-MED课题组,德国莱比锡04103

出　　处：《中华中医药学刊》2024年第9期13-17,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274684);中国中医科学院科技创新工程项目(CI2021A05409);中国中医科学院基本科研业务费自主选题项目(ZZ150316)。

摘　　要：中西药物联用是国内医疗界和学术界共同关注的焦点问题之一。目前,中西药相互作用信息化研究基本处于数据库构建探索阶段,相关研究成果较少;中西药相互作用类别及途径信息不完整,相关数据来源单一,检索结果缺乏证据评价;存在信息分散、缺乏统一语义参照等问题,难以满足本领域理论研究与临床合理用药的需要。在大语言模型的技术背景下,探讨基于本体推理和语义网检索的中西药相互作用知识发现方法。首先,解析中西药相互作用领域概念及关系,构建中西药相互作用本体;其次,在中西药联合使用时,根据设定的中西药相互作用规则发现隐含的中西药相互作用信息知识,利用语义检索获得的中西药相互作用结果,制定评价指标,通过对中西药相互作用结果的证据等级推荐,对中西药联用场景进行风险预警提示;最后,构建中西药相互作用知识图谱并开发应用示范系统。同时,积极探索借助大语言模型的多任务处理功能,辅助信息抽取、结构化和知识表示,知识发现结果智能输出。The combination of traditional Chinese and Western medicine is one of the focal issues of common concern in do-mestic medical and academic circles.At present,the information technology research on the interaction between traditional Chi-nese and Western medicine is basically in the exploration stage of database construction,and there are relatively few related re-search results.There is incomplete information on the types and pathways of interactions between traditional Chinese and Western medicine,single data sources and lack of evidence evaluation in search results.There are problems such as scattered information and lack of unified semantic reference,which are difficult to meet the needs of theoretical research and rational clinical drug use in this field.In the technical background of large language model,this study initially explored the knowledge discovery method of traditional Chinese and Western medicine based on ontology reasoning and semantic web retrieval.First,it analyzes the concepts and relationships in the field of interaction between traditional Chinese and Western medicine,and constructs the ontology of in-teraction between traditional Chinese and Western medicine.Secondly,when traditional Chinese and Western medicines are used in combination,based on the set rules of interaction between traditional Chinese and Western medicine,the hidden knowledge of interaction between traditional Chinese and Western medicine is discovered.The results of interaction between traditional Chinese and Western medicine obtained through semantic retrieval are used to develop the evaluation indicators.By recommending the ev-idence level of the results of interaction between traditional Chinese and Western medicine,the risk warning prompts are provided for the scenario of combination of traditional Chinese and Western medicine.Finally,the knowledge map of traditional Chinese and Western medicine interactions is constructed and an application demonstration system is developed.At the same time,it ac-tively explores the c

关 键 词：中西药物相互作用 本体推理 语义网检索 知识发现 

分 类 号：R2-03[医药卫生—中医学]