聚桂醇泡沫硬化剂与原液硬化剂在内镜下硬化治疗出血倾向内痔应用中的比较  

Comparison of lauromacrogol foam and raw liquid sclerosing agentin endoscopic sclerotherapy for bleeding prone internal hemorrhoids

作　　者：张鹏 方新鑫 韩怡 ZHANG Peng;FANG Xinxin;HAN Yi(Department of Gastroenterology,The Affiliated Fuyang Hospital of Anhui Medical University,Fuyang Anhui 236000,China)

机构地区：[1]安徽医科大学附属阜阳医院消化内科,安徽阜阳236000

出　　处：《蚌埠医学院学报》2024年第8期1020-1024,共5页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究项目(KJ2021A0339);安徽医科大学校科研基金项目(2022xkj068)。

摘　　要：目的:探讨内镜下硬化治疗出血倾向内痔中使用聚桂醇泡沫硬化剂与原液硬化剂的差异。方法:选择行内镜下硬化治疗出血倾向内痔的病人108例,分为聚桂醇泡沫硬化剂组(FS组)及原液硬化剂组(LS组),观察2组在治疗效果、病人评价、操作过程的差异。结果:在治疗结束时FS组局部出血、肛周疼痛、肛周不适的发生率小,满意度高,差异有统计学意义(P<0.05~P<0.01)。在术后24 h时FS组肛周疼痛、肛周不适的发生率小,满意度高,差异均有统计学意义(P<0.01)。术后2周时FS组疗效好,差异均有统计学意义(P<0.05),2组在肛周疼痛及肛周不适的发生率、治疗有效率、病人满意度差异均无统计学意义(P>0.05)。术后4周时FS组疗效、治疗有效率及满意度高,差异均有统计学意义(P<0.01),2组肛周疼痛及肛周不适的发生率差异无统计学意义(P>0.05)。2组并发症发生率的差异无统计学意义(P>0.05)。FS组聚桂醇原液使用量、注射总位点数少,差异均有统计学意义(P<0.01)。结论:聚桂醇泡沫硬化剂在内镜下硬化治疗出血倾向内痔的应用中具有更高的临床应用价值。Objective:To investigate the difference between lauromacrogol foam and raw liquid sclerosing agent in the use of endoscopic sclerotherapy for bleeding prone internal hemorrhoids.Methods:One hundred and eight patients with bleeding tendency of internal hemorrhoids were selected,and divided into laurofoam sclerosing agent group(FS group)and raw liquid sclerosing agent group(LS group).The differences of treatment effect,patient evaluation and operation process in two groups were observed.Results:At the end of treatment,the incidence artes of local bleeding,perianal pain,and perianal discomfort in the FS group were lower than those in LS group(P<0.05 to P<0.01).After 24 hours of surgery,the incidence rates of perianal pain and discomfort were lower,and the satisfaction was higher in the FS group than those in LS group(P<0.01).After 2 weeks of surgery,the therapeutic effects in the FS group was better than that in LS group(P<0.05),and there was no statistical significance in the incidence rates of perianal pain and discomfort,treatment effectiveness and patient satisfaction betwen two groups(P>0.05).After 4 weeks of operation,the differences of treatment effectiveness and satisfaction between two groups were statistically significant(P<0.01),and there was no statistical significance in the incidence rates of perianal pain and discomfort between two groups(P>0.05).There was no statistical significance in the incidence of complications between two groups(P>0.05).The differences of the usage amount of laurofoam and total number of injection sites between two groups were statistically significant(P<0.01).Conclusions:The clinical application value of poly(cinnamyl alcohol)foam sclerosing agent in endoscopic sclerotherapy of bleeding prone internal hemorrhoids is high.

关 键 词：痔 内镜下硬化治疗 聚桂醇 泡沫硬化剂 原液硬化剂 

分 类 号：R657.18[医药卫生—外科学]