间歇低氧对哺乳动物学习记忆能力影响的Meta分析  

Meta-analysis of the Effects of Intermittent Hypoxia on Learning and Memory in Mammals

作　　者：姚桢 张子微 吴春淼 张靖楠 李庆华 王振龙 YAO Zhen;ZHANG Ziwei;WU Chunmiao;ZHANG Jingnan;LI Qinghua;WANG Zhenlong(School of Life Sciences,Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学生命科学学院,郑州450000

出　　处：《实验动物科学》2024年第4期49-55,共7页Laboratory Animal Science

基　　金：中原科技创新领军人才(224200510001)。

摘　　要：目的本文针对现有Morris水迷宫实验结果进行分析,探讨间歇低氧对哺乳动物学习记忆能力的影响。方法通过检索中国知网(CNKI)、维普、万方、Web of Science、PubMed、Elsevier等数据库,根据纳入及排除标准筛选文献,检索时间限定为建库到2023年2月25日。使用RevMan 5.3软件对提取的数据进行统计学分析,主要分析间歇低氧对鼠在Morris水迷宫实验中逃避潜伏期和跨越目标象限时间的影响。随后采用敏感性分析的方法对所纳入研究的质量进行评价。结果本研究共纳入24篇文章,263个研究对象。Meta分析结果显示,在Morris水迷宫实验中,相较于对照组,在间歇低氧2周后鼠逃避潜伏期增长[SMD=4.17,95%CI(3.46,4.89),P<0.01];而鼠跨越目标象限时间缩短[SMD=-3.07,95%CI(-3.56,-2.58),P<0.01]。在间歇低氧4周后鼠逃避潜伏期长于对照组[SMD=8.03,95%CI(6.21,10.40),P<0.01];跨越目标象限时间缩短[SMD=-6.79,95%CI(-8.60,-4.99),P<0.01]。结论在间歇低氧不同时间后,鼠在水迷宫中的逃避潜伏期增长;而跨越目标象限时间缩短,即表现出学习记忆能力受损。Objective Existing studies have shown that hypoxia affects mammalian brain function.In this paper,Morris water maze experiment was employed to analyze the effects of intermittent hypoxia on learning and memory ability of lactation.Method The retrieval time was limited to February 25,2023 through the databases of CNKI,VIP database,WANFANG data,Web of Science,PubMed and Elsevier.RevMan 5.3 software was used for statistical analysis of the extracted data,Then sensitivity analysis was used to evaluate the quality of the included studies.Result A total of 24 articles and 263 subjects were included in this study.In the Morris Water Maze experiments,the escape latency of rats/mice was increased after treated with intermittent hypoxia for two weeks compared with the control group[SMD=4.17,95%CI(3.46,4.89),P<0.01].The time of rats/mice crossing the target quadrant was decreased[SMD=-3.07,95%CI(-3.56,-2.58),P<0.01].After treatment with intermittent hypoxia for four weeks,the escape latency increased[SMD=8.03,95%CI(6.21,10.40),P<0.01];The time across the target quadrant shortened[SMD=-6.79,95%CI(-8.60,-4.99),P<0.01].Conclusion Treated with intermittent hypoxia,the escape latency of rats/mice in the water maze rises,and the time of cross the target quadrant is shortened,indicating the learning and memory ability of mice/rats is impaired.

关 键 词：间歇低氧 META分析 水迷宫 

分 类 号：Q95-3[生物学—动物学]