小鼠抑郁症模型的构建与评估  

Construction and Evaluation of Mouse Depression Models

作　　者：王金辉 张勇[1] 董伟韬 张全伟[1] WANG Jinhui;ZHANG Yong;DONG Weitao;ZHANG Quanwei(College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730000,China)

机构地区：[1]甘肃农业大学动物医学院,兰州730000

出　　处：《实验动物科学》2024年第4期75-79,共5页Laboratory Animal Science

摘　　要：抑郁症因逐年升高的发病率已经受到了医学界的广泛关注。抑郁症发病因素极其复杂,因此在进行相关实验时构建相应抑郁症模型成为实验关键步骤。本文主要介绍常见小鼠抑郁症模型的构建方法,例如慢性不可预见性温和刺激模型,特殊药物所致抑郁模型,生命早期应激模型等,以及相关评估抑郁程度的行为学实验,例如强迫游泳实验、蔗糖偏好实验、喷溅实验等,为相关研究人员提供实验思路及方法。Depression has received widespread attention from the medical community due to its increasing incidence year by year.The factors of depression are extremely complex,so the construction of depression models has become a key step when conducting related experiments.This paper mainly introduces the construction method of common mouse depression models,such as chronic unpredictable mild stimulus model,special drug-induced depression model,early life stress model,etc.,and related behavioural experiments to assess the degree of depression,such as forced swimming experiment,sucrose preference experiment,splashing experiment,etc.,which provide relevant researchers with experimental ideas and method.

关 键 词：抑郁症 动物模型 行为学评估 

分 类 号：Q95-3[生物学—动物学]