胚胎期颞下颌关节形态发育研究进展  

Research Progress on Morphological Development of Temporomandibular Joint During Embryonic Stage

作　　者：相磊 王学文 刘华蔚 常平 母晓丹 胡敏 XIANG Lei;WANG Xuewen;LIU Huawei;CHANG Ping;MU Xiaodan;HU Min(Department of Animial Laboratory,Institute of Orthopaedic Trauma,Jishuitan Hospital,Beijing 100035,China;Institute for Laboratory Animal Resources,National Institutes for Food and Drug Control,Beijing 102629,China;Department of Stomatology,the First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]北京积水潭医院创伤骨科研究所动物实验室,北京100035 [2]中国食品药品检定研究院实验动物资源所,北京102629 [3]中国人民解放军总医院第一医学中心口腔科,北京100853

出　　处：《实验动物科学》2024年第4期85-91,共7页Laboratory Animal Science

基　　金：北京市卫生健康委员会基金(BJRIO-RDP-2023)。

摘　　要：颞下颌关节(TMJ)是哺乳动物特有的滑膜关节,其发育过程与长骨关节有着显著的不同。TMJ胚胎发育研究已有近百年的历史,然而一方面人类TMJ胚胎发育研究的连续性受到限制,TMJ发育起始以及髁突骨化与生长方式等问题还尚未完全阐明;另一方面啮齿类动物作为TMJ发育研究的模式动物与人类TMJ还存在一定的差异,寻求与人更为接近的模式动物开展TMJ胚胎发育研究的脚步从未停止。本文从人类与动物模型两个方面对胚胎期TMJ的形态发育进行了综述。Temporomandibular joint(TMJ)is a synovial joint unique to mammals and its development process is significantly different from that of long bone joints.The study of embryonic development in TMJ has nearly one hundred years history.However,on the one hand,the continuity of human TMJ embryo development research is limited.The initiation of TMJ development and the condyle ossification and growth patterns have not yet been fully elucidated in human.On the other hand,there are some differences between rodents as model animals for TMJ development research and human.Seeking model animals similar to human to carry out TMJ embryo development research has never stopped.This article reviews the morphological development of embryonic TMJ including human and animal models.

关 键 词：颞下颌关节 胚胎发育 模型动物 

分 类 号：Q95-3[生物学—动物学]