Epidemiology of congenital diaphragmatic hernia among 24 million Chinese births:a hospital-based surveillance study  

作　　者：Zhi-Yu Chen Jing Tao Wen-Li Xu Yu-Yang Gao Wen-Yan Li Zhen Liu Jia-Yuan Zhou Li Dai 

机构地区：[1]National Center for Birth Defects Monitoring,West China Second University Hospital,Sichuan University,No.17 Section 3 Renminnanlu,Chengdu 610041,China [2]The Joint Laboratory for Pulmonary Development and Related Diseases,West China Institute of Women and Children’s Health,West China Second University Hospital,Sichuan University,Chengdu,China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,Sichuan University,Chengdu,China [4]NHC Key Laboratory of Chronobology,Sichuan University,Chengdu,China [5]Med‑X Center for Informatics,Sichuan University,Chengdu,China

出　　处：《World Journal of Pediatrics》2024年第7期712-722,共11页世界儿科杂志（英文版）

基　　金：supported by National Health Commission of China.

摘　　要：Background The prevalence of congenital diaphragmatic hernia(CDH)varies across countries,with limited information available on its epidemiology in China.Our study aimed to investigate the prevalence,time trends,and perinatal outcomes of CDH in China,as well as its associated malformations and potential associations with maternal and infant characteristics.Methods This study included all birth and CDH cases from the Chinese Birth Defects Monitoring Network between 2007 and 2019,with CDH cases classified as either isolated or associated.We employed the joinpoint regression model to calculate the trends of prevalence and the annual percent change,with Poisson regression used for adjusted prevalence rate ratios.A P value≤0.05 was considered statistically significant.Results A total of 4397 CDH cases were identified among 24,158,029 births in the study period,yielding prevalence rates of 1.82,1.13 and 0.69 per 10,000 for overall,isolated,and associated CDH,respectively.The prevalence of each type of CDH increased over time.The prevalence of overall CDH varied significantly by infant sex(male vs.female,1.91/10,000 vs.1.63/10,000),maternal residence(urban vs.rural,2.13/10,000 vs.1.45/10,000),maternal age(<20 years,1.31/10,000;20-24 years,1.63/10,000;25-29 years,1.80/10,000;30-34 years,1.87/10,000;≥35 years,2.22/10,000),and geographic region(central,1.64/10,000;east,2.45/10,000;west,1.37/10,000).Cardiovascular anomalies were the most common malformations associated with CDH.Infants with associated CDH had a higher risk of premature birth and perinatal death than those with isolated CDH.Conclusion The increasing prevalence and high perinatal mortality rate of CDH highlight the need for further etiological,epidemiological,and clinical studies among the Chinese population.

关 键 词：China Congenital diaphragmatic hernia EPIDEMIOLOGY PREVALENCE 

分 类 号：R722.1[医药卫生—儿科]