Magnetic resonance imaging of knees:a novel approach to predict recombinant human growth hormone therapy response in short-stature children in late puberty  

作　　者：Xi Bai Zhi‑Bo Zhou Xiao‑Yuan Guo Yi‑Ling He Yue‑Lun Zhang Feng‑Dan Wang Feng Feng Hong‑Bo Yang Shi Chen Feng‑Ying Gong Hui‑Juan Zhu Hui Pan 

机构地区：[1]Department of Endocrinology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong,China [2]Key Laboratory of Endocrinology of National Health Commission,Department of Endocrinology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [3]Medical Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [4]Department of Radiology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing,China

出　　处：《World Journal of Pediatrics》2024年第7期723-734,共12页世界儿科杂志（英文版）

基　　金：supported by the CAMS Innovation Fund for Medical Science(CIFMS 2021-I2M-1-003);National High Level Hospital Clinical Research Funding(2022-PUMCH-B-016).

摘　　要：Background There is no appropriate tool to predict recombinant human growth hormone(rhGH)response before therapy initiation in short-stature children in late puberty.The current study aimed to explore the associations between magnetic resonance imaging(MRI)stages of the knee growth plates and rhGH response in short-stature children in late puberty.Methods In this prospective cohort study,short-stature children in late puberty were treated with rhGH and followed up for 6 months.We proposed a novel knee MRI staging system according to the growth plate states of distal femurs or proximal tibias and divided the participants into three groups:unclosed growth plate group,marginally closed growth plate group,and nearly closed growth plate group.The primary outcomes were height gain and growth velocity(GV),which were assessed three months later.Results Fifty participants were enrolled,including 23 boys and 27 girls.GV and height gain after 6 months of rhGH therapy decreased successively in the three groups with an increased degree of growth plate fusion,especially when grouped by proximal tibias(GV_(1-3 mon)from 9.38 to 6.08 to 4.56 cm/year,GV_(4-6 mon)from 6.75 to 4.92 to 3.25 cm/year,and height gain from 4.03 to 2.75 to 1.95 cm,all P<0.001).Moreover,the MRI stages of growth plates independently served as a significant variable for GV and height gain after therapy,especially when grouped by proximal tibias(all P<0.01).Conclusion The MRI staging method is expected to be an effective tool for predicting rhGH response before therapy initiation in short-stature children in late puberty.

关 键 词：Growth hormone Growth velocity Late puberty Magnetic resonance imaging Short stature 

分 类 号：R72[医药卫生—儿科] R445[医药卫生—临床医学]