Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine  

作　　者：Peiyao Xu Ranjith Kumar Kankala Shibin Wang Aizheng Chen 

机构地区：[1]Institute of Biomaterials and Tissue Engineering,Huaqiao University,Xiamen,Fujian 361021,PR China [2]Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University),Xiamen,Fujian 361021,PR China

出　　处：《Regenerative Biomaterials》2024年第3期1-29,共29页再生生物材料（英文版）

基　　金：the National Natural Science Foundation of China(NSFC 32271410,32071323 and 81971734);the Science and Technology Projects in Fujian Province(2022FX1,2023Y4008);Scientific Research Funds of Huaqiao University(21BS113);the Open Research Fund of Academy of Advanced Carbon Conversion Technology,Huaqiao University(AACCT0004).

摘　　要：Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue engineering,the clinical transformation of these scaffolds remained a big challenge because of the difficulty of simulating native organs/tissues'microenvironment.As a kind of natural tissue-derived biomaterials,decellularized extracellular matrix(dECM)-based scaffolds have gained attention due to their unique biomimetic properties,providing a specific microenvironment suitable for promoting cell proliferation,migration,attachment and regulating differentiation.The medical applications of dECM-based scaffolds have addressed critical challenges,including poor mechanical strength and insufficient stability.For promoting the reconstruction of damaged tissues or organs,dif-ferent types of dECM-based composite platforms have been designed to mimic tissue microenvironment,including by integrating with natural polymer or/and syntenic polymer or adding bioactive factors.In this review,we summarized the research progress of dECM-based composite scaffolds in regenerative medicine,highlighting the critical challenges and future perspectives related to the medical application of these composite materials。

关 键 词：decellularized extracellular matrix POLYMER bioactive factors COMPOSITES tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]