青海省杂多县鼠疫菌病原学特征及流行病学分析  

Pathogenic Characteristics and Epidemiological Significance of Yersinia Pestis in Zaduo County,Qinghai Province

作　　者：张晓璐 代瑞霞[1] 熊浩明[1] 辛有全[1] 杨晓艳[1] 李广辉 靳娟[1] 张丽 李存香[1] ZHANG Xiaolu;DAI Ruixia;XIONG Haoming;XIN Youquan;YANG Xiaoyan;LI Guanghui;JIN Juan;ZHANG Li;LI Cunxiang(Qinghai Institute for Endemic Diseases Control and Prevention,Xining 810021,China)

机构地区：[1]青海省地方病预防控制所,青海西宁810021

出　　处：《青海畜牧兽医杂志》2024年第4期24-27,共4页Chinese Qinghai Journal of Animal and Veterinary Sciences

基　　金：青海省医药卫生科技项目重点课题(2022-wjzd-06)。

摘　　要：分析青海省杂多县鼠疫菌病原及流行病学特征,为该地区的鼠疫防控监测工作提供科学依据。对1964—1989年青海省杂多县不同宿主体内分离的21株鼠疫菌进行生化糖醇类试验、毒力因子(荚膜抗原(F1+)、毒力抗原因子(VW+)、色素沉着因子(Pgm+)、鼠疫杆菌素I(Pst1+))检测、质粒及菌株差异区段(Different region,DFR)分型等研究。结果发现:21株菌株均为青藏高原型,90.48%的鼠疫菌4个毒力因子俱全;所有菌株均携带分子质量为6×10^(6)、45×10^(6)和65×10^(6)的质粒;DFR分型结果显示,5型占90.48%,32型占4.76%,1b型占4.76%。青海省杂多县鼠疫菌具备青藏高原鼠疫病原体特性,该地区鼠疫菌毒力强,应加强鼠疫监测和宣传力度,防止鼠疫波及影响加剧。To analyze the etiological characteristics and epidemiological significance of yersinia pestis in Zaduo County,Qinghai Province,and to provide scientific basis for plague prevention and control surveillance in this area.Biochemical glycoalcohol test,(virulence factor(F1+),virulence factor(VW+),pigmentation factor(Pgm+),yersinia pestis 1(Pet1+),plasmid and bacterial difference region(different)were performed in 21 strains of Yersinia pestis isolated from different Jukings in Qinghai Province from 1964 to 1989 Region-dpr)classification and other research.Results All the 21 strains were Tibetan plateau type,90.48% of yersinia pestis had all the four virulence factors,and all the strains carried plasmid with molecular weight of 6×10^(6),45×10^(6).65×10^(6).DFR typing results showed that type 5 accounted for 90.48%,type 32 accounted for 4.76% and type 1b accounted for 4.76%.The Yersinia pestis in Zaduo County of Qinghai Province has the characteristics of plague pathogen in Qinghai-Tibet Plateau,and the Yersinia pestis has strong virulence.The plague surveillance and publicity should be strengthened in this area to prevent the plague from spreading to human.

关 键 词：鼠疫耶尔森菌 病原学 流行病学 杂多县 

分 类 号：R516.8[医药卫生—内科学]