适配体在眼科应用中的研究进展  

Research Progress of the Application of Aptamers in Ophthalmology

作　　者：岑佳盈 林恒伊 赵云娥[1,2] 邴涛 CEN Jiaying;LIN Hengyi;ZHAO Yune;BING Tao(School of Optometry&Ophthalmology,Wenzhou Medical University,Wenzhou 325000,China;Eye Hospital,Wenzhou Medical University,Wenzhou 325000,China;Zhejiang Cancer Hospital/Zhejiang Provincial Key Laboratory for Aptamers and Clinical Diagnosis and Treatment/Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310018,China)

机构地区：[1]温州医科大学眼视光学院,浙江温州325000 [2]温州医科大学附属眼视光医院,浙江温州325000 [3]浙江省肿瘤医院浙江省核酸适体与临床诊治重点实验室中国科学院杭州医学研究所,浙江杭州310018

出　　处：《药学进展》2024年第8期605-612,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.82371042,No.22274139);浙江省自然科学基金(No.YXD24B0401);浙江省“尖兵”“领雁”研发攻关计划项目(No.2023SDYXS0002);国家卫生健康委科学研究基金-浙江省卫生健康重大科技计划项目(No.WKJ-ZJ-2424)。

摘　　要：适配体因其靶向性和易于化学合成等特性而被广泛地应用于诊断和治疗研究。由于眼部解剖结构的独立性和特殊性,适配体能够在眼科领域起到独特的作用。目前已有系列适配体在眼科疾病领域的研究报道,包括2个上市的适配体。综述就有关适配体的特点,及其在眼科疾病年龄相关性黄斑变性、青光眼、甲状腺相关性眼病及眼肿瘤中的研究进展进行了介绍。Aptamers are widely used in diagnostic and therapeutic research due to their targeting and ease of chemical synthesis.Aptamers can play a unique role in ophthalmology due to the independence and specificity of the eye’s anatomy.At present,a series of aptamers have been reported in the field of ophthalmic diseases,including two aptamers approved.This review introduces the characteristics of aptamers and their research progress in age-related macular degeneration,glaucoma,thyroid associated ophthalmopathy,and ocular tumors.

关 键 词：适配体 年龄相关性黄斑变性 青光眼 甲状腺相关性眼病 眼肿瘤 

分 类 号：Q524[生物学—生物化学]