工程化外泌体在药物递送研究中的进展  

Research Progress of Engineered Exosomes in Drug Delivery

作　　者：崔璟 张燕[1] 张宁坤 陈宇[1,2] CUI Jing;ZHANG Yan;ZHANG Ningkun;CHEN Yu(Department of Cardiology,The Sixth Medical Center of Chinese People’s Liberation Army General Hospital,Beijing 100048,China;Navy Clinical College,The Fifth School of Clinical Medicine,Anhui Medical University,Hefei 230032,China)

机构地区：[1]解放军总医院第六医学中心心内科,北京1000891 [2]安徽医科大学第五临床医学院海军临床学院,安徽合肥2030032

出　　处：《药学进展》2024年第8期633-640,共8页Progress in Pharmaceutical Sciences

基　　金：北京市自然科学基金(No.722183);国家重点研发计划项目(No.2022YFA1104300)。

摘　　要：外泌体是由多种细胞分泌的囊泡样结构,粒径范围约为40~160 nm。工程化外泌体是目前药物递送研究中的热点,其工程化手段包括改变装载模式以改变外泌体的内含分子、靶向功能,以及利用外泌体的优势与组织工程学材料相结合等。综述构建工程化外泌体的方式、外泌体结合组织工程学材料的应用以及外泌体体内分布的影响因素,以阐明当前工程化外泌体在药物递送方面的研究进展,为后续的外泌体临床应用提供一定的参考。Exosomes are vesicular structures secreted by a variety of cells,with a size of approximately 40-160 nm.The engineering of exosomes is currently a hot topic in drug delivery research.Engineering methods include changing the loading mode to alter the contents and targeting functionality of exosomes,and combining the advantages of exosomes with tissue engineering materials.This article reviews the methods of constructing engineered exosomes,the application of exosomes combined with tissue engineering materials,and the influencing factors of exosomes'distribution in vivo to elucidate the current research progress of engineered exosomes in drug delivery,aiming to provide some reference for the subsequent clinical application of exosomes.

关 键 词：靶向给药 药物载体 外泌体 工程化修饰 组织工程 

分 类 号：R943[医药卫生—药剂学]