富马酸卢帕他定与复方甘草酸苷联合对慢性荨麻疹患者活动度、瘙痒症状和血清IgE、SAA和IFN-γ水平的影响  

Effects of Lupatadine Fumarate Combined with Compound Glycyrrhizin on Activity,Pruritus Symptoms and Serum IgE,SAA and IFN-γLevels in Patients with Chronic Urticaria

作　　者：唐卓润 梁天梅[1] TANG Zhuorun;LIANG Tianmei(Sihui City People's Hospital,Sihui 526200,China;不详)

机构地区：[1]四会市人民医院,广东四会526200

出　　处：《中外医学研究》2024年第24期25-28,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究富马酸卢帕定与复方甘草酸苷联合对慢性荨麻疹患者的活动度、瘙痒症状、血清免疫球蛋白E(IgE)、血清淀粉样蛋白A(SAA)和干扰素-γ(IFN-γ)水平的影响。方法:选取2022年8月—2023年8月四会市人民医院就诊的80例慢性荨麻疹患者作为研究对象,使用随机数表法分为对照组和治疗组,每组各40例。对照组予以富马酸卢帕他定片治疗,治疗组予以富马酸卢帕定联合复方甘草酸苷治疗。治疗1个月后,比较两组荨麻疹活动度评分(UAS)、瘙痒症状评分及血清IgE、SAA、IFN-γ的水平变化情况。结果:治疗后,两组荨麻疹活动度的评分较治疗前下降,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗后,两组瘙痒症状评分较治疗前下降,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清IgE、SAA水平均较治疗前下降,IFN-γ水平较治疗前升高,且治疗组的上述指标变化幅度高于对照组,差异有统计学意义(P<0.05)。结论:富马酸卢帕他定联合复方甘草酸苷治疗慢性荨麻疹可以更有效改善患者的荨麻疹活动度和瘙痒症状,并且在患者的免疫病理机制中起重要作用。Objective:To investigate the effects of the combination of fumarate and compound glycyrrhizin on activity,itching symptoms,serum immunoglobulin E(IgE),serum amyloid A(SAA),and Interferon-γlevels in patients with chronic urticaria.Method:Eighty patients with chronic urticaria who visited the hospital from August 2022 to August 2023 were selected as the study objects and randomly divided into a control group and a treatment group,with 40 cases in each groups.The control group was treated with lupatadine fumarate tablets,while the treatment group was treated with lupatadine fumarate combined with compound glycyrrhizic acid glycoside.After one month of treatment,the urticaria activity score(UAS),itching symptom score,serum IgE,SAA,and IFN-γwere compared between the two groups of patients.Result:After treatment,the score of urticaria activity in both groups of patients decreased compared with those before treatment,and the score of patients in the treatment group was lower than that in the control group(P<0.05).After treatment,the itching symptom scores of the two groups of patients decreased compared with those before treatment,and the symptom scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum IgE and SAA levels of both groups of patients decreased compared with those before treatment,The level of IFN-γincreased compared with those before treatment,and the changes in the above indicators in the treatment group were higher than those in the control group(P<0.05).Conclusion:The combination of lupatadine fumarate and compound glycyrrhizic acid glycoside in the treatment of chronic urticaria can effectively improve urticaria activity and itching symptoms in patients,and play an important role in the immunopathological mechanism of patients.

关 键 词：富马酸卢帕他定 复方甘草酸苷 慢性荨麻疹 干扰素-γ 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]