甲泼尼龙结合临床干预路径治疗小儿哮喘性支气管炎的临床疗效  

Clinical Efficacy of Methylprednisolone Combined with Clinical Intervention Pathway in the Treatment of Asthmatic Bronchitis in Children and Its Effect on Symptom Improvement Time

作　　者：黄爱军 卞志操 朱志萍[1] HUANG Aijun;BIAN Zhicao;ZHU Zhiping(Dongtai People's Hospital,Dongtai 224200,China;不详)

机构地区：[1]东台市人民医院,江苏东台224200

出　　处：《中外医学研究》2024年第24期79-82,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析甲泼尼龙与临床干预路径治疗小儿哮喘性支气管炎的疗效。方法:选取2020年3月—2023年3月东台市人民医院收治的80例哮喘性支气管炎患儿作为研究对象,以随机数表法分为对照组和观察组,每组各40例。对照组患儿接受注射用甲泼尼龙琥珀酸钠治疗,观察组患儿接受甲泼尼龙结合临床干预路径治疗,分析临床疗效及对症状改善时间的影响。结果:观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);观察组症状消失时间短于对照组,差异有统计学意义(P<0.05);观察组治疗后血清白细胞介素-4(IL-4)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平低于对照组,差异有统计学意义(P<0.05)。结论:甲泼尼龙结合临床干预路径治疗小儿哮喘性支气管炎有助于提高临床疗效,缩短症状改善时间,促进炎症反应消退。Objective:To analyze the efficacy of methylprednisolone and clinical intervention in pediatric asthmatic bronchitis.Method:A total of 80 children with asthmatic bronchitis treated in Dongtai People's Hospital from March 2020 to March 2023 were selected as the study objects and randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with methylprednisolone for injection sodium succinate,and the observation group received methylprednisolone combined with clinical intervention pathway,and the clinical curative effect and influence on symptom improvement time were analyzed.Result:The total clinical effective rate of observation group was higher than of control group(P<0.05).The symptom disappearance time of observation group was shorter than control group,and the difference was statistically significant(P<0.05).Serum levels of interleukin-4(IL-4),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in observation group after treatment were lower than those in control group,and the difference was statistically significant(P<0.05).Conclusion:Methylprednisolone combined with clinical intervention pathway in the treatment of asthmatic bronchitis in children can improve the clinical effect,shorten the time of symptom improvement and promote the regression of inflammation.

关 键 词：甲泼尼龙 临床干预路径 哮喘性支气管炎 临床疗效 症状改善时间 

分 类 号：R725.6[医药卫生—儿科]