左炔诺孕酮宫内节育系统联合达英-35在宫腔镜下子宫内膜息肉电切术后的应用效果评估  

Evaluation of the Application Effect of Levonorgestrel Intrauterine Contraceptive System Combined with Dane-35 after Hysteroscopic Resection of Endometrial Polyps

作　　者：王洁 石念月 胡芳 WANG Jie;SHI Nianyue;HU Fang(Zhijiang People's Hospital,Zhijiang 443200,China;不详)

机构地区：[1]枝江市人民医院,湖北枝江443200

出　　处：《中外医学研究》2024年第24期87-90,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:评估左炔诺孕酮宫内节育系统(LNG-IUS)联合达英-35在宫腔镜下子宫内膜息肉电切术(TCRP)后的应用效果。方法:选取2022年3月—2023年3月枝江市人民医院行TCRP的72例子宫内膜息肉(EP)患者作为研究对象,采用随机分层法分为单一组和联合组,每组各36例。TCRP后两组均给予常规药物治疗,单一组在此基础上使用达英-35治疗,联合组使用LNG-IUS联合达英-35进行治疗。比较用药6个周期后两组性激素水平、子宫内膜厚度、月经量[月经失血图(PBAC)]、EP复发情况及不良反应发生情况。结果:治疗6个周期后两组黄体生成素(LH)水平较治疗前明显升高,乱跑刺激素(FSH)、孕酮(Prog)及雌二醇(E2)水平较治疗前均明显降低,联合组各项水平变化均较单一组更明显;治疗6个周期后两组的子宫内膜厚度及PBAC评分较治疗前均明显降低,联合组降低幅度较单一组更明显,差异有统计学意义(P<0.05),差异有统计学意义(P<0.05);联合组的不良反应发生率高于单一组,差异无统计学意义(P>0.05)。结论:LNG-IUS联合达英-35在TCRP后应用能获得良好的治疗效果,不仅调节EP患者性激素水平,减少子宫内膜厚度,还可促使月经量恢复正常,降低患者EP复发,其安全性良好。Objective:To evaluate the application effect of levonorgestrel intrauterine device(LNG-IUS)combined with Diane-35 in hysteroscopic endometrial polypectomy(TCRP).Method:72 patients with endometrial polyps(EP)who underwent TCRP in the hospital from March 2022 to March 2023 were selected and randomly divided into a single group and a combination group using a random stratification method,with 36 cases in each group.After TCRP,the two groups were given conventional drug treatment,the single group was treated with Diane-35 on this basis,and the combined group was treated with LNG-IUS combined with Diane-35.The levels of sex hormones,endometrial thickness,menstrual volume[menstrual bleeding chart(PBAC)],recurrence of EP and incidence of adverse reactions were compared between the two groups of patients after 6 cycles of medication.Result:After 6 cycles of treatment,LH levels in both groups significantly increased compared with those before treatment,while FSH,Prog and E2 levels significantly decreased compared with those before treatment.The combined group showed more significant changes in all levels compared with the single group,there were significant differences.After 6 cycles of treatment,the endometrial thickness and PBAC score of both groups were significantly reduced compared with those before treatment,and the combined group had a more significant reduction than the single group.The incidence of adverse reactions in the combination group was higher than that in the single group(P>0.05).Conclusion:The combination of LNG-IUS and Diane-35 can achieve good therapeutic effects after TCRP.It not only regulates the levels of sex hormones in EP patients,reduces endometrial thickness,but also promotes the return of menstrual flow to normal and reduces EP recurrence in patients.Its safety performance is good.

关 键 词：左炔诺孕酮宫内节育系统 达英-35 宫腔镜子宫内膜息肉电切术 

分 类 号：R713.4[医药卫生—妇产科学]