地黄叶总苷胶囊治疗糖尿病肾病的随机对照研究  

A Randomized Controlled Study of Total Glycosides of Rehmannia Glutinosa Leaves Capsules for Diabetic Nephropathy

作　　者：郭敏[1] 杜跃亮[1] 林静[1] GUO Min;DU Yueliang;LIN Jing(Luohe Central Hospital,Luohe 462000,Henan,China)

机构地区：[1]漯河市中心医院,河南漯河462000

出　　处：《辽宁中医杂志》2024年第9期67-71,共5页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨地黄叶总苷胶囊治疗糖尿病肾病的临床疗效及对患者肾功能、血糖指标的改善效果。方法2019年1月—2021年1月漯河市中心医院收治的糖尿病肾病患者150例按随机数字表法分为观察组和对照组,各75例。观察组与对照组均给予常规治疗。观察组同时给予地黄叶总苷胶囊口服治疗。两组患者均连续治疗6个月。将观察组与对照组患者各项指标(治疗后的临床疗效,治疗前后的肾功能、血糖、血液流变学、炎症因子及治疗期间的不良反应)进行统一的对比与分析。结果治疗后经组间统计学比较发现,观察组与对照组的总有效率分别为92.00%(69/75)、72.00%(54/75),观察组患者的临床总有效率明显更高;治疗后观察组与对照组患者的血肌酐(creatinine,SCr)、血尿素氮(blood urea nitrogen,BUN)、β2微球蛋白(β2 microglobulin,U-β2MG)、24 h尿蛋白总量、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 h postprandial blood glucose,2 h PG)、糖化血红蛋白(glycated hemoglobin,HbA1c)、血液流变学各项指标、血清白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)、细胞内细胞黏附分子-1(intracellular cell adhesion molecule-1,ICAM-1)水平与治疗前比较,均呈现降低的趋势,且较对照组而言,观察组明显处于较低水平;两组患者内生肌酐清除率(creatinine clearance,Ccr)均呈现升高趋势,且较对照组而言,观察组明显处于较高水平,差异有统计学意义(P<0.05)。结论糖尿病肾病患者应用地黄叶总苷胶囊治疗可有效控制其血糖水平,改善肾功能,减轻炎症反应,调节血液流变学指标,具有较高的临床疗效及安全性。Objective To investigate the clinical efficacy of Total Glycosides of Rehmannia Glutinosa Leaves Capsules in the treatment of diabetic nephropathy and its effect on renal function and blood glucose indexes.Methods A total of 150 patients with diabetes nephropathy admitted to Luohe Central Hospital from January 2019 to January 2021 were divided into observation group and control group according to random number table,75 cases in each.All patients were treated with usual treatment,and the observation group was also given oral treatment with Total Glycosides of Rehmannia Glutinosa Leaves Capsules.Both groups were continuously treated for 6 months.A unified comparison and analysis were made between the observation group and the control group on various indicators(clinical efficacy after treatment,renal function,blood glucose,hemorheology,inflammatory factors before and after treatment and adverse reactions during treatment).Results After treatment,statistical comparison between groups showed that the total effective rate of the observation group and the control group was 92.00%(69/75)and 72.00%(54/75),respectively.The clinical total effective rate of the observation group tended to be significantly higher.Compared with those before treatment,creatinine(SCr),blood urea nitrogen(BUN),β2 microglobulin(U-β2MG),24-h total urine protein,fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG),glycated hemoglobin(HbA1c),the indexes of hemorheology,serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),monocyte chemotactic protein(MCP-1)and intracellular cell adhesion molecule-1(ICAM-1)of both groups showed a decreasing trend,and the levels of the observation group were significantly lower than those of the control group.The intrinsic creatinine clearance(Ccr)of both groups showed a increasing trend,and the level of the observation group was significantly higher than that of the control group,and the statistical calculation showed a significant difference(P<0.05).Con

关 键 词：糖尿病肾病 地黄叶总苷胶囊 肾功能 血糖 血液流变学 炎症因子 

分 类 号：R256.5[医药卫生—中医内科学]