半夏泻心汤联合常规西医治疗脾虚湿热型2型糖尿病的效果评价  

Effect Evaluation of Banxia Xiexin Decoction(半夏泻心汤)Combined with Conventional Western Medicine in Treatment of Spleen Deficiency Damp-Heat Syndrome of Type 2 Diabetes Mellitus with

作　　者：车名花 戴欣珏 陈婧 王青 姚丽琴 CHE Minghua;DAI Xinjue;CHEN Jing;WANG Qing;YAO Liqin(Yixing Hospital of Traditional Chinese Medicine,Wuxi 214200,Jiangsu,China)

机构地区：[1]宜兴市中医医院,江苏无锡214200

出　　处：《辽宁中医杂志》2024年第9期84-87,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨脾虚湿热型2型糖尿病经半夏泻心汤联合常规西医治疗后的临床效果。方法宜兴市中医医院2020年1月—2022年3月收治的脾虚湿热型2型糖尿病患者100例,分为观察组、对照组,每组50例。给予对照组患者常规西医治疗。在对照组治疗方案的基础上,给予观察组患者半夏泻心汤进行治疗,均给予两组患者12周的治疗时间。对比两组患者治疗后临床疗效,治疗前后中医证候积分、血脂、血糖、血清超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平,治疗期间安全性。结果经比较两组患者治疗后的临床总有效率得出,观察组比对照组更高;治疗后,两组患者血清总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、餐后2 h血糖(2-hour postprandial blood glucose,2 h PG)、MDA、IL-6、TNF-α水平、胰岛素抵抗指数(homeostasis model assessment insulin resistance,HOMA-IR)、各项中医证候主症、次症评分与治疗前比较,均呈现降低趋势,其中与对照组比较,观察组处于较低水平;两组患者血清高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、SOD水平、胰岛β细胞功能指数(homeostasis model assessment-β,HOMA-β)与治疗前比较,均呈现升高趋势,其中与对照组比较,观察组处于较高水平,差异有统计学意义(P<0.05)。结论半夏泻心汤联合常规西医治疗脾虚湿热型2型糖尿病效果显著,可改善患者中医证候,调节血糖血脂水平,同时有助于减轻机体氧化应激及炎性损伤。Objective To investigate the clinical effect of Banxia Xiexin Decoction(半夏泻心汤)combined with conventional Western medicine spleen deficiency and dampness-heat syndrome of type 2 diabetes mellitus.Methods A hundred patients with spleen-deficiency damp-heat syndrome of type 2 diabetes mellitus treated in the hospital were selected from January 2020 to March 2022,and were divided into the observation group and the control group,with 50 cases in each group.The patients in the control group were given routine western medicine treatment.On the basis of the treatment plan of the control group,those in the observation group were given Banxia Xiexin Decoction in combination.Both groups were given 12 weeks of treatment.The clinical efficacy,TCM syndrome scores,the levels of blood lipid,blood glucose,serum superoxide dismutase(SOD),malondialdehyde(MDA),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)before and after treatment and the safety during treatment were compared between the two groups.Results By comparing the clinical total effective rates of two groups after treatment,the total effective rate of the observation group was higher than that of the control group.After treatment,the serum levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin(HbA1c),2-hour postprandial blood glucose(2 h PG),MDA,IL-6,TNF-αand homeostasis model assessment insulin resistance(HOMA-IR)and the scores of main and secondary symptoms of TCM syndrome in both groups showed a decreasing trend compared with those before treatment,and those of the observation group were at a lower level than those of the control group.Compared with those before treatment,the levels of serum high-density lipoprotein cholesterol(HDL-C)and SOD and(homeostasis model assessment-β(HOMA-β)values of the two groups showed an increasing trend.Compared with that of the control group,the indexes of the observation group were at a higher level(P<0.05),indicating a significant difference in data afte

关 键 词：2型糖尿病 脾虚湿热型 半夏泻心汤 常规西医 临床效果 中医证候 血脂 血糖 

分 类 号：R255.4[医药卫生—中医内科学]