活血续断汤加减联合骨肽注射液在腰椎骨折术后骨组织修复中的效果研究  

Study on effect of modified Huoxue Xuduan Decoction combined with ossotide injection on postoperative bone tissue repair of lumbar spine fractures

作　　者：赵波 郑庆祥 ZHAO Bo;ZHENG Qing-xiang(Second Orthopedic Department,Jinan Integrated Traditional Chinese and Western Medicine Hospital,Jinan 271100,China)

机构地区：[1]济南市中西医结合医院骨二科,271100

出　　处：《中国实用医药》2024年第17期35-38,共4页China Practical Medicine

摘　　要：目的探究在腰椎骨折术后骨组织修复中联合使用骨肽注射液与活血续断汤加减治疗的临床效果。方法选取76例腰椎骨折手术患者为研究对象,随机划分为对照组与研究组,各38例。对照组患者术后给予骨肽注射液治疗,研究组患者术后在对照组基础上使用活血续断汤加减治疗。对比两组患者治疗效果、骨性标志物水平、骨密度以及椎体功能。结果研究组患者治疗总有效率为94.74%,显著高于对照组的76.32%,统计学对比差异显著(P<0.05);研究组患者骨钙素(BGP)(5.24±1.49)μg/L、骨碱性磷酸酶(BALP)(5.37±1.24)U/L、Ⅰ型前胶原羧基端肽(PⅠCP)(150.92±23.76)μg/L均高于对照组的(3.73±1.19)μg/L、(4.01±0.77)U/L、(120.74±20.41)μg/L,总Ⅰ型前胶原氨基端延长肽(Total-PⅠNP)(35.12±7.27)ng/ml、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)(0.28±0.04)ng/ml比对照组的(46.88±8.52)、(0.44±0.07)ng/ml更低,统计学对比差异显著(P<0.05);研究组患者治疗后骨密度为(1.23±0.14)g/cm^(2),显著高于治疗前的(0.91±0.12)g/cm^(2),且比对照组的(1.01±0.12)g/cm^(2)更高,统计学对比差异显著(P<0.05);治疗后,研究组患者疼痛评分(3.73±0.36)分、后凸Cobb角(6.63±0.51)°均低于对照组的(5.41±0.25)分、(11.18±1.26)°,椎体前缘高度百分比(68.51±1.07)%高于对照组的(62.87±1.21)%,统计学对比差异显著(P<0.05)。结论使用骨肽注射液与活血续断汤加减能够有效促进腰椎骨折术后骨组织修复效果提升,有效减轻疼痛情况,提高患者椎体功能与骨密度,且能够改善骨性标志物水平,从而促进患者康复。Objective To explore the clinical effect of modified Huoxue Xuduan Decoction combined with ossotide injection on postoperative bone tissue repair of lumbar spine fractures.Methods 76 postoperative patients with lumbar spine fractures were selected as the study subjects.They were randomly divided into a control group and a study group,with 38 patients in each group.The control group was treated with ossotide injection,and the study group was treated with modified Huoxue Xuduan Decoction based on the control group.The treatment effect,bone marker levels,bone density,and vertebral function of the two groups were compared.Results The total effective rate of the study group was 94.74%,which was significantly higher than 76.32%of the control group,and the difference was statistically significant(P<0.05).In the study group,the bone gla protein(BGP)was(5.24±1.49)μg/L,the bone alkaline phosphatase(BALP)was(5.37±1.24)U/L and typeⅠprocollagen amino-terminal peptide(PⅠCP)was(150.92±23.76)μg/L,which were higher than(3.73±1.19)μg/L,(4.01±0.77)U/L and(120.74±20.41)μg/L in the control group;the total procollagen typeⅠN-terminal propeptide(total-PⅠNP)was(35.12±7.27)ng/ml,and the beta C-terminal cross-linked telopeptides of typeⅠcollagen(β-CTX)was(0.28±0.04)ng/ml,which were lower than(46.88±8.52)and(0.44±0.07)ng/ml in the control group;the difference was statistically significant(P<0.05).After treatment,the bone mineral density of the study group was(1.23±0.14)g/cm^(2),which was significantly higher than(0.91±0.12)g/cm^(2)before treatment,and(1.01±0.12)g/cm^(2)of the control group.The difference was statistically significant(P<0.05).After treatment,the study group had pain score of(3.73±0.36)points and the Cobb's angle of kyphosis of(6.63±0.51)°,which were lower than(5.41±0.25)points and(11.18±1.26)°in the control group;the percentage of anterior vertebral body heights of(68.51±1.07)%in the study group was higher than(62.87±1.21)%in the control group.The difference was statistically significant(

关 键 词：骨肽 活血续断汤 腰椎骨折 术后修复 骨组织修复 

分 类 号：R687.3[医药卫生—骨科学]