头孢克肟联合左氧氟沙星治疗慢性肺炎的疗效研究  

Study on the efficacy of cefixime combined with levofloxacin in the treatment of chronic pneumonia

作　　者：李华 LI Hua(Health Center of Songbai Town of Wulian County,Rizhao 262300,China)

机构地区：[1]日照市五莲县松柏镇卫生院,262300

出　　处：《中国实用医药》2024年第17期107-109,共3页China Practical Medicine

摘　　要：目的分析慢性肺炎使用头孢克肟联合左氧氟沙星治疗的效果。方法78例慢性肺炎患者,按照治疗方式不同分为对照组和研究组,每组39例。对照组采取左氧氟沙星治疗,研究组在对照组基础上联合头孢克肟治疗。比较两组的治疗效果,治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]水平,临床症状消失时间。结果研究组治疗总有效率97.44%明显高于对照组的79.49%,差异具有统计学意义(P<0.05)。治疗后,两组TNF-α、CRP、IL-6、IL-8水平均较本组治疗前明显下降,且研究组TNF-α(10.29±3.38)pg/L、CRP(6.75±1.62)mg/L、IL-6(13.05±3.42)pg/ml、IL-8(8.37±1.63)μg/L均低于对照组的(16.33±3.29)pg/L、(13.82±3.14)mg/L、(18.95±3.17)pg/ml、(13.04±2.05)μg/L,差异具有统计学意义(P<0.05)。研究组咳嗽、咳痰、气促、肺啰音消失时间分别为(3.75±1.05)、(3.16±0.52)、(2.19±0.41)、(3.17±1.05)d,均短于对照组的(5.05±1.31)、(4.69±0.35)、(3.82±0.55)、(5.62±1.33)d,差异具有统计学意义(P<0.05)。结论慢性肺炎患者使用头孢克肟联合左氧氟沙星治疗的效果更好,能明显降低机体的炎症反应,改善患者的临床症状,应进一步推广应用。Objective To analyze the effect of cefixime combined with levofloxacin in the treatment of chronic pneumonia.Methods 78 patients with chronic pneumonia were divided into a control group and a study group according to different treatment methods,with 39 cases in each group.The control group was treated with levofloxacin,while the study group was treated with cefixime.Comparison was made on therapeutic effect,levels of inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8)]and disappearance time of clinical symptoms between the two groups.Results The total effective rate of 97.44%in the study group was significantly higher than 79.49%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-α,CRP,IL-6 and IL-8 in both groups were significantly decreased compared with those before treatment;the study group had TNF-αof(10.29±3.38)pg/L,CRP of(6.75±1.62)mg/L,IL-6 of(13.05±3.42)pg/ml and IL-8 of(8.37±1.63)μg/L,which were lower than(16.33±3.29)pg/L,(13.82±3.14)mg/L,(18.95±3.17)pg/ml and(13.04±2.05)μg/L in the control group;the difference was statistically significant(P<0.05).In the study group,the disappearance time of cough,sputum,shortness of breath and pulmonary rales were(3.75±1.05),(3.16±0.52),(2.19±0.41)and(3.17±1.05)d,which were shorter than(5.05±1.31),(4.69±0.35),(3.82±0.55)and(5.62±1.33)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Cefixime combined with levofloxacin has a better effect in the treatment of chronic pneumonia patients,which can significantly reduce the inflammatory response of the body and improve the clinical symptoms of patients,and should be further recommended.

关 键 词：慢性肺炎 头孢克肟 左氧氟沙星 炎性因子 效果 

分 类 号：R563.1[医药卫生—呼吸系统]