Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.  

作　　者：Patrícia Michelle Nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira 

机构地区：[1]Department of Biosciences and Oral Diagnosis,Institute of Science and Technology,São Paulo State University,São Josédos Campos 12245000,SP,Brazil [2]Anhembi Morumbi University,School of Medicine,São Josédos Campos 12230-002,SP,Brazil [3]Department of Restorative Dentistry,Endodontics Division,Institute of Science and Technology,São Paulo State University,São Josédos Campos 12245000,São Paulo,Brazil

出　　处：《World Journal of Critical Care Medicine》2024年第3期63-74,共12页世界重症医学杂志

摘　　要：BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral diseases.AIM To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,Ca.dubliniensis,and Ca.krusei.METHODS Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute documents.The synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay.Data were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS C.schoenanthus and P.graveolens essential oils were as effective as 0.12%chlorhexidine against S.mutans and St.aureus monotypic biofilms after 24 h.After 24 h P.graveolens essential oil at 0.25%was more effective than the nystatin group,and C.schoenanthus essential oil at 0.25%was as effective as the nystatin group.CONCLUSION C.schoenanthus and P.graveolens essential oils are effective against S.mutans,St.aureus,Ca.albicans,Ca.dubliniensis,and Ca.krusei at different concentrations after 5 min and 24 h.

关 键 词：Antifungal effect LEMONGRASS GERANIUM Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans 

分 类 号：R96[医药卫生—药理学]