Contemporary nationwide trends in major adverse cardiovascular events in young cannabis users without concomitant tobacco,alcohol,cocaine use  

作　　者：Rupak Desai Priyatham Gurram Adil S Mohammed Rishabh B Salian Shanmukh Sai Pavan Lingamsetty Sandeep Guntuku Ravi Venkata Sai Krishna Medarametla Rawnak Jahan Zainab Muslehuddin Paritharsh Ghantasala 

机构地区：[1]Department of Outcomes Research,Independent Researcher,Atlanta,GA 30033,United States [2]Department of Internal Medicine,Central Michigan University College of Medicine,Saginaw,MI 48602,United States [3]Department of Medicine,Kasturba Medical College,Mangalore 575001,India [4]Department of Medicine,Mamata Medical College,Khammam 507002,India [5]Department of Medicine,Bangladesh Medical College,Dhaka 110015,Bangladesh [6]Department of Internal Medicine,Wayne State University,Sinai Grace Hospital,Detroit Medical Center,Detroit,MI 48201,United States

出　　处：《World Journal of Cardiology》2024年第9期512-521,共10页世界心脏病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Cannabis use has increased among young individuals in recent years.Although dependent cannabis use disorder(CUD)has been associated with various cardiac events,its effects on young adults without concurrent substance use remain understudied.AIM To examine trends in hospitalizations for major adverse cardiac and cerebrovascular events(MACCE)in this cohort.METHODSWe used the National Inpatient Sample(2016-2019)to identify hospitalized young individuals(18-44 years),excluding those with concurrent substance usage(tobacco,alcohol,and cocaine).They were divided into CUD+and CUD-.Using International Classification of Diseases-10 codes,we examined the trends in MACCE hospitalizations,including all-cause mortality(ACM),acute myocardial infarction(AMI),cardiac arrest(CA),and acuteischemic stroke(AIS).RESULTSOf 27.4 million hospitalizations among young adults without concurrent substance abuse,4.2%(1.1 million)hadco-existent CUD.In CUD+group,hospitalization rates for MACCE(1.71%vs 1.35%),AMI(0.86%vs 0.54%),CA(0.27%vs 0.24%),and AIS(0.49%vs 0.35%)were higher than in CUD-group(P<0.001).However,rate of ACMhospitalizations was lower in CUD+group(0.30%vs 0.44%).From 2016 to 2019,CUD+group experienced arelative rise of 5%in MACCE and 20%in AMI hospitalizations,compared to 22%and 36%increases in CUDgroup(P<0.05).The CUD+group had a 13%relative decrease in ACM hospitalizations,compared to a 10%relative rise in CUD-group(P<0.05).However,when adjusted for confounders,MACCE odds among CUD+cohort remain comparable between 2016 and 2019.CONCLUSIONThe CUD+group had higher rates of MACCE,but the rising trends were more apparent in the CUD-group overtime.Interestingly,the CUD+group had lower ACM rates than the CUD-group.

关 键 词：CANNABIS Major adverse cardiac and cerebrovascular events Myocardial infarction Cardiac arrest Stroke Allcause mortality Young adults TRENDS 

分 类 号：R54[医药卫生—心血管疾病]